کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8476336 | 1550805 | 2018 | 43 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation
ترجمه فارسی عنوان
مقررات استروئیدی: یک جنبه نادیده گرفته شده از تحمل و رد پای مزمن در پیوند کلیه
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کلمات کلیدی
CNIGambitKTR11β-HSDNR3C1T-regHprtppifFOXP3H6PD11β-hydroxysteroid dehydrogenaseTVSPNOCIQRRT-qPCRNR3C2C1sCVSPBMCStat1 - sTAT1regulatory T-cells - T-cell های نظارتیTolerance - تلرانس Kidney transplant recipients - دریافت کنندگان پیوند کلیهchronic rejection - رد مزمنperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیinterquartile range - محدوده بین محدبCalcineurin inhibitors - مهار کننده های کالسینورینquantitative real-time reverse transcriptase polymerase chain reaction - واکنش زنجیره ای پلی مراز ترانس کریتاز معکوس در زمان واقعی معکوسTransplantation - پیوندKidney - کلیهhealthy controls - کنترل های سالمCISH - کیشGilz - گیلز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with “operational tolerance” and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (nâ¯=â¯17), stable (nâ¯=â¯190) and CR patients (nâ¯=â¯37) were compared. Healthy controls (nâ¯=â¯14) were used as reference. The anti-inflammatory glucocorticoid receptor (NR3C1) and the cortisol-activating HSD11B1 and H6PD genes were up-regulated in CR and were lowest in tolerant patients. The pro-inflammatory mineralocorticoid gene (NR3C2) was downregulated in stable and CR patients. NR3C1 was associated with neutrophils and NR3C2 with T-cells. Steroid conversion and receptor genes, alone, enabled classification of tolerant patients and were major contributors to gene-expression signatures of both, tolerance and CR, alongside known tolerance-associated genes, revealing a key role of steroid regulation and response in kidney transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 473, 15 September 2018, Pages 205-216
Journal: Molecular and Cellular Endocrinology - Volume 473, 15 September 2018, Pages 205-216
نویسندگان
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Estefania Nova-Lamperti, Sonia Norris, Yogesh Kamra, Rachel Hilton, Sunil Bhandari, Richard Baker, David Berglund, Sue Carr, David Game, Sian Griffin,