کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8477207 | 1550886 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production
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کلمات کلیدی
PKCANGIIPKDAngiotensin II (AngII)Src family kinases - kinases خانواده Srcaldosterone - آلدوسترون zona glomerulosa - آنها glomerulosaAngiotensin II - آنژیوتانسین دوdiacylglycerol - دیسیل گلیسیرینDAG - روزProtein kinase C (PKC) - پروتئین کیناز C (PKC)protein kinase D - پروتئین کیناز DProtein kinase C - پروتئین کیناز سیAdrenal glomerulosa - گلومرولوز آدنال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production Protein kinase C and Src family kinases mediate angiotensin II-induced protein kinase D activation and acute aldosterone production](/preview/png/8477207.png)
چکیده انگلیسی
Recent evidence has shown a role for the serine/threonine protein kinase D (PKD) in the regulation of acute aldosterone secretion upon angiotensin II (AngII) stimulation. However, the mechanism by which AngII activates PKD remains unclear. In this study, using both pharmacological and molecular approaches, we demonstrate that AngII-induced PKD activation is mediated by protein kinase C (PKC) and Src family kinases in primary bovine adrenal glomerulosa cells and leads to increased aldosterone production. The pan PKC inhibitor Ro 31-8220 and the Src family kinase inhibitors PP2 and Src-1 inhibited both PKD activation and acute aldosterone production. Additionally, like the dominant-negative serine-738/742-to-alanine PKD mutant that cannot be phosphorylated by PKC, the dominant-negative tyrosine-463-to-phenylalanine PKD mutant, which is not phosphorylatable by the Src/Abl pathway, inhibited acute AngII-induced aldosterone production. Taken together, our results demonstrate that AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 392, Issues 1â2, 5 July 2014, Pages 173-181
Journal: Molecular and Cellular Endocrinology - Volume 392, Issues 1â2, 5 July 2014, Pages 173-181
نویسندگان
Lawrence O. Olala, Brian A. Shapiro, Todd C. Merchen, James J. Wynn, Wendy B. Bollag,