Congenital hypothyroidism alters the oxidative status, enzyme activities and morphological parameters in the hippocampus of developing rats

- Hypothyroidism inhibits glutamate uptake and increases Ca2+ influx in rat hippocampus.
- The glutamate-glutamine cycle is compromised by hypothyroid condition.
- Hypothyroidism leads to decreased neuronal and glial cell population in hippocampus.
- Oxidative stress is involved in neural cell damage caused by hypothyroidism.
- S100B could be a biomarker of brain damage in hypothyroidism during development.