Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia

► Hyperglycemia frequently develops during acute stroke. ► We model cerebral ischemia to study the mechanisms of hyperglycemia. ► Hepatic expression of gluconeogenic genes and transcription factors is increased. ► Insulin resistance develops in liver with elevated glucagon and inflammation. ► Enhanced hepatic gluconeogenesis contributes to post-stroke hyperglycemia.