Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development

► Conditional mouse models illuminated the role of hepatic GH-STAT5 and GC-GR signaling in liver function. ► We provide an overview of overlapping and distinct functions of hepatic GH-STAT5 and GC-GR signaling in growth/metabolism. ► Impaired hepatic GH-STAT5 signaling sensitizes hepatocytes to injury and tumorigenic transformation. ► Loss of hepatic GR function causes chronic stress, thereby aggravating liver cancer formation upon impaired STAT5 function.