Molecular mechanisms of temperature-dependent sex determination in the context of ecological developmental biology

► In the red-eared slider, gonad sex is determined by incubation temperature. ► Exogenous ligands override the temperature during development, modifying gonad sex. ► Exogenous ligands reversed temperature-typical expression of FoxL2 and Dmrt1. ► In the model, FoxL2 and Dmrt1 may be critical factors in sex determining pathway.