Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes

► Dio2 transcription in rat pinealocytes is highly sensitive to inhibitors of aurora kinase. ► Dio2 transcription is sensitive to nM concentration of trichostatin A. ► ChIP with antibodies against acetylated Lys14 of H3 shows an increase in DNA recovery of the promoter region of Dio2. ► Histone modifications have minimal effect on the transcription of Fra2. ► Histone modifications appear to play an important role in rhythmic gene expression.