کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8477950 | 1550934 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biochemistry and physiology of hexose-6-phosphate knockout mice
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کلمات کلیدی
DKOG6P11β-HSD111-dehydrocorticosterone11-DHCG6PDH11β-hydroxysteroid dehydrogenase type 1UPRG6PTH6PDHNADPHNADP+ - NADP +Sarcoplasmic reticulum - رتیکولوم سارکوپلاسمیکendoplasmic reticulum - شبکه آندوپلاسمی Muscle - عضلهMetabolism - متابولیسم Knockout mice - موش نابود شدهHPA - میلی بار یا هکتوپاسکالknockout - ناکاوتwild type - نوع وحشیnicotinamide adenine dinucleotide phosphate (reduced) - نیکوتین آمید adenine dinucleotide phosphate (کاهش)Hexose-6-phosphate dehydrogenase - هگزوز 6-فسفات دهیدروژنازhypothalamic-pituitary-adrenal - هیپوتالاموس-هیپوفیز-آدرنالUnfolded protein response - پاسخ پروتئین آشکارglucose-6-phosphate - گلوکز 6-فسفاتglucose-6-phosphate dehydrogenase - گلوکز 6-فسفات دهیدروژنازGlucocorticoid - گلوکوکورتیکوئیدها
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Hexose-6-phosphate dehydrogenase (H6PDH) has emerged as an important factor in setting the redox status of the endoplasmic reticulum (ER) lumen. An important role of H6PDH is to generate a high NADPH/NADP+ ratio which permits 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) to act as an oxo-reductase, catalyzing the activation of glucocorticoids (GCs). In H6PDH knockout mice 11β-HSD1 assumes dehydrogenase activity and inactivates GCs, rendering the target cell relatively GC insensitive. Consequently, H6PDHKO mice have a phenotype consistent with defects in the permissive and adaptive actions of GCs upon physiology. H6PDHKO mice have also offered an insight into muscle physiology as they also present with a severe vacuolating myopathy, abnormalities of glucose homeostasis and activation of the unfolded protein response due to ER stress, and a number of mechanisms driving this phenotype are thought to be involved. This article will review what we understand of the redox control of GC hormone metabolism regulated by H6PDH, and how H6PDHKO mice have allowed an in-depth understanding of its potentially novel, GC-independent roles in muscle physiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 336, Issues 1â2, 10 April 2011, Pages 213-218
Journal: Molecular and Cellular Endocrinology - Volume 336, Issues 1â2, 10 April 2011, Pages 213-218
نویسندگان
Agnieszka E. Zielinska, Elizabeth A. Walker, Paul M. Stewart, Gareth G. Lavery,