کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8478555 | 1551139 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci](/preview/png/8478555.png)
چکیده انگلیسی
Genome-wide association studies have identified twenty loci associated with late-onset Alzheimer disease (LOAD). We examined each of the twenty loci, specifically the ± 50 kb region surrounding the most strongly associated variant, for changes in gene(s) transcription specific to LOAD. Post-mortem human brain samples were examined for expression, methylation, and splicing differences. LOAD specific differences were detected by comparing LOAD to normal and “disease” controls. Eight loci, prominently ABCA7, contain LOAD specific differences. Significant changes in the CELF1 and ZCWPW1 loci occurred in genes not located nearest the associated variant, suggesting that these genes should be investigated further as LOAD candidates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 67, July 2015, Pages 37-45
Journal: Molecular and Cellular Neuroscience - Volume 67, July 2015, Pages 37-45
نویسندگان
Crystal Humphries, Martin A. Kohli, Patrice Whitehead, Deborah C. Mash, Margaret A. Pericak-Vance, John Gilbert,