Alterations in NADPH oxidase expression and blood-brain barrier in bile duct ligation-treated young rats: Effects of melatonin

► Model of hepatic encephalopathy in young rat. ► Increase prefrontal cortex NADPH oxidase activity and NADPH subunits expression. ► Increase brain intercellular adhesion molecule-1 and tissue plasminogen activator gene expression. ► Decreases prefrontal cortex occludin gene expression. ► Melatonin has therapeutic effects.