کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8479486 | 1551342 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Src family kinases (SFKs) and cell polarity in the testis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Src family kinases (SFKs) and cell polarity in the testis Src family kinases (SFKs) and cell polarity in the testis](/preview/png/8479486.png)
چکیده انگلیسی
Non-receptor Src family kinases (SFKs), most notably c-Src and c-Yes, are recently shown to be expressed by Sertoli and/or germ cells in adult rat testes. Studies have shown that SFKs are involved in modulating the cell cytoskeletal function, and involved in endocytic vesicle-mediated protein endocytosis, transcytosis and/or recycling as well as intracellular protein degradation events. Furthermore, a knockdown to SFKs, in particular c-Yes, has shown to induce defects in spermatid polarity. These findings, coupled with emerging evidence in the field, thus prompt us to critically evaluate them to put forth a developing concept regarding the role of SFKs and cell polarity, which will become a basis to design experiments for future investigations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 81, September 2018, Pages 46-53
Journal: Seminars in Cell & Developmental Biology - Volume 81, September 2018, Pages 46-53
نویسندگان
Xiang Xiao, Ya Ni, Chenhuan Yu, Linxi Li, Baiping Mao, Yue Yang, Dongwang Zheng, Bruno Silvestrini, C. Yan Cheng,