کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8479971 | 1551351 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MACPF/CDC proteins in development: Insights from Drosophila torso-like
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کلمات کلیدی
SMaseTMHMACPFRTKIL-12perivitelline spaceINRPVSBRINPTSLTORmRNACDCSPZMAPK - MAPKSpätzle - spaetzleStreptolysin O - استرپتولیسین Oacid sphingomyelinase - اسفنجی مینولیز اسیدslo - اسلوinterleukin-12 - اینترلوکین -12Torso - تاب گشتTrk - تراکTrunk - تنهtumour necrosis factor-alpha - تومور نکروز عامل آلفاPTTH - دبیرستانPVR - ضبط و پخشprothoracic gland - غدد پروستاتیکTNF-α - فاکتور نکروز توموری آلفاElectron microscopy - میکروسکوپ الکترونیProthoracicotropic hormone - هورمون Prothoracicotropicmitogen activated protein kinase - پروتئین کیناز فعال Mitogen فعال استInsulin-like receptor - گیرنده انسولین مانندReceptor Tyrosine Kinase - گیرنده تیروزین کیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: MACPF/CDC proteins in development: Insights from Drosophila torso-like MACPF/CDC proteins in development: Insights from Drosophila torso-like](/preview/png/8479971.png)
چکیده انگلیسی
The Membrane Attack Complex Perforin-like/Cholesterol-Dependent Cytolysin (MACPF) superfamily is an ancient and biologically diverse group of proteins that are best known for pore-forming roles in mammalian immunity and bacterial pathogenesis. Intriguingly, however, some eukaryotic proteins which contain the MACPF domain that defines this family do not act in attack or defence, and instead have distinct developmental functions. It remains unclear whether these proteins function via pore formation or have a different mechanism of action. Of these, by far the best characterised is Torso-like (Tsl), the only MACPF member that has been identified in the fruit fly, Drosophila melanogaster. While it has long been known to have a role in embryonic patterning, recent studies have shown that Tsl in fact has multiple roles in development. As such, it presents an excellent opportunity to investigate how the MACPF domain functions in a developmental context. Here, we review what is known about Tsl in Drosophila and other insects, and discuss the potential molecular mechanism by which Tsl and thus other developmental MACPF proteins may function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 72, December 2017, Pages 163-170
Journal: Seminars in Cell & Developmental Biology - Volume 72, December 2017, Pages 163-170
نویسندگان
Travis K. Johnson, Michelle A. Henstridge, Coral G. Warr,