Keywords: اسفنجی مینولیز اسید; DR; diabetic retinopathy; EPC; endothelial progenitor cell; DME; diabetic macular edema; EC; endothelial cells; VTDR; vision-threatening diabetic retinopathy; PDR; proliferative diabetic retinopathy; NVI; neovascularization in the iris; IOP; intraocular p
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Keywords: اسفنجی مینولیز اسید; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
Keywords: اسفنجی مینولیز اسید; Sphingolipid; Lipopolysaccharide; Lung injury; Ceramide; Inflammation; Enzyme inhibitors; ARDS; Acute respiratory distress syndrome; LPS; lipopolyssacharide; ASM; acid sphingomyelinase; NSM; neutral sphingomyelinase; SPT; serine palmitoyl transferase; DS;
Keywords: اسفنجی مینولیز اسید; ASMase; acid sphingomyelinase; BAEC; bovine aortic endothelial cells; BrdU; 5-bromo-2â²-deoxyuridine; bSMase; bacterial sphingomyelinase; CNT; concentrative nucleoside transporter; dFdC; 2â²,2â²-difluoro 2â²-deoxycytidine; EDTA; ethylene diamine tetra
Keywords: اسفنجی مینولیز اسید; AA; arachidonic acid (20:4n-6); ABHD; α,β-hydrolase; AC; acid ceramidase; AEA; N-arachidonoylethanolamide; 2-AG; 2-arachidonoylglycerol; AD; Alzheimer's disease; ALA; α-linolenic acid (18:3n-3); ASM; acid sphingomyelinase; AMPA; alpha-amino-3-hydroxy
Keywords: اسفنجی مینولیز اسید; VEGF; vascular endothelial growth factor; PDGF; platelet derived growth factor; EC; endothelial cells; STV; saline-base trypsin versene; EDTA; Ethylenediaminetetraacetic acid; FBS; fetal bovine serum; PBS; phosphate buffered saline; HEPES; 4-(2-hydroxyeth
Keywords: اسفنجی مینولیز اسید; LSD; lysosomal storage disease; CNS; central nervous system; BBB; blood-brain barrier; ERT; enzyme replacement therapy; GAG; glycosaminoglycans; CSF; cerebrospinal fluid; FDA; food and drug administration; ICV; intracerebroventricular; HLA; human leukocyt
Keywords: اسفنجی مینولیز اسید; Ceramide; Bioactive lipids; Acid sphingomyelinase; Myocardial ischemia;
Keywords: اسفنجی مینولیز اسید; 4-DP; 4â²-deoxypridoxine; ABC transporter; ATP-binding cassette transporter; Akt; protein kinase B; ALF4; tetrafluoroaluminate; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; ASM; acid sphingomyelinase; BACE1; beta-site APP-cleaving e
Keywords: اسفنجی مینولیز اسید; 4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; aCDase; acid ceramidase; Akt; Akt/protein kinase B; aSMase; acid sphingomyelinase; CalA; calyculin A; CAPP; ceramide activated protein phosphatase; CDase; ceramidase; Cer; ceramide; Des
Keywords: اسفنجی مینولیز اسید; Cholesterol transfer of NPC2; Regulation of acid sphingomyelinase; Tay Sachs disease; Regulation of ganglioside catabolism; Lipid modifiers; ASM; acid sphingomyelinase; BMP; bis(monoacylglycero)-phosphate; CAD; cationic amphiphilic drug; DOPC; dioleoyl-l-
Keywords: اسفنجی مینولیز اسید; 3-MA; 3-methyladenine; 6-OHDA; 6-hydroxydopamine; AD; Alzheimer's disease; AIF; apoptosis inducing factor; ALR; autophagosome-lysosome reformation; ALS; amyotrophic lateral sclerosis; AMD; age- dependent macular degeneration; ApoE; apolipoprotein E; APP
Keywords: اسفنجی مینولیز اسید; Acc; acetyl-CoA carboxylase; ASM; acid sphingomyelinase; ATP; adenosine triphosphate; ATPase; adenosine triphosphatase; ATX; autotaxin; BMP; bis(monoacylglycero)phosphate; CDP; cytidine diphosphate; CL; cardiolipin; CNS; central nervous system; COPI; coat
Keywords: اسفنجی مینولیز اسید; Caliciviruses; Endosomal escape; Replication; Acid sphingomyelinase; Ceramide formation;
Keywords: اسفنجی مینولیز اسید; AC; acid ceramidase; ACTH; adrenocorticotropic hormone; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ASM; acid sphingomyelinase; BDNF; brain-derived nerve growth factor; CB1; cannabinoid 1 receptor; CDP-DAG; cytidine diphosphate diacylg
Keywords: اسفنجی مینولیز اسید; ALT; alanine transaminase; ASM; acid sphingomyelinase; AST; aspartate transaminase; CE; cholesteryl ester; Cer; ceramide; FC; free cholesterol; GGT; gamma-glutamyl transpeptidase; GOT; glutamic oxaloacetic transaminase; GPL; glycerophospholipid; GPT; glut
Keywords: اسفنجی مینولیز اسید; depression; ceramide; acid sphingomyelinase; inflammation; neurogenesis; stress
Keywords: اسفنجی مینولیز اسید; ABCA12; ATP binding cassette subfamily A member 12; ASM; acid sphingomyelinase; CE; cornified envelope; Cer; ceramide; CerS; ceramide synthase; ELOVL; fatty acid elongase; FA; fatty acid; GlcCer; glucosylceramide; LB; lamellar bodies; PPAR; peroxisome pro
Keywords: اسفنجی مینولیز اسید; ALD; alcohol induced liver disease; ASMase; acid sphingomyelinase; BHMT; betaine homocysteine methyl transferase; CBS; cystathionine-β-synthase; DGAT2; diacylglycerol transferase 2; ER; endoplasmic reticulum; FAS; fatty acid synthase; Hcy; homocysteine;
Lipidomic signature of serum from the rats exposed to alcohol for one year
Keywords: اسفنجی مینولیز اسید; GGT; gamma-glutamyl-transpeptidase; CDT; carbohydrate deficient transferring; EtG; ethyl glucuronide; HDL; high-density lipoprotein; NMR; nuclear magnetic resonance; Q-TOF/MS; quadrupole time of flight mass spectrometry; FIDs; free induction decays; PLS-D
Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis
Keywords: اسفنجی مینولیز اسید; Nonalcoholic Fatty Liver Disease; Triglycerides; Fatty Acids; Therapy; AA; arachidonic acid; ACC; acetyl-coenzyme A carboxylase; ASMase; acid sphingomyelinase; CeS; ceramide synthase; CoA; coenzyme A; COX; cyclo-oxygenase; DES; dihydro-ceramide desatura
Discovery of N-hydroxy-3-alkoxybenzamides as direct acid sphingomyelinase inhibitors using a ligand-based pharmacophore model
Keywords: اسفنجی مینولیز اسید; Acid sphingomyelinase; Inhibitors; Pharmacophore model; Anti-apoptosis; Anti-inflammatory;
Trypanosoma cruzi modulates gene expression of plasma membrane repair-related proteins
Keywords: اسفنجی مینولیز اسید; Trypanosoma cruzi; Membrane repair; Dysferlin; Acid sphingomyelinase; Transcriptional factor EB; Gene expression; Host interaction;
Research paperAlternative splicing of SMPD1 coding for acid sphingomyelinase in major depression
Keywords: اسفنجی مینولیز اسید; Acid sphingomyelinase; Alternative splicing; Major depression; Functional inhibitors of ASM activity (FIASMAs); Antidepressant drugs; Fluoxetine; Paroxetine;
Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR
Keywords: اسفنجی مینولیز اسید; Paclitaxel resistance; Human prostate cancer cell line; SPHK1; Glucosylceramide synthase; Sphingomyelinase; Sphingolipid rheostat; ACDase; acid ceramidase; ASMase; acid sphingomyelinase; DNR; daunorubicin; GCS; glucosylceramide synthase; LC-MS/MS; liquid
Research paperBurn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner
Keywords: اسفنجی مینولیز اسید; Burn injury; T cells; Butyrate; Acid sphingomyelinase; Apoptosis;
MACPF/CDC proteins in development: Insights from Drosophila torso-like
Keywords: اسفنجی مینولیز اسید; ASTN; Astrotactin; BRINP; Bone Morphogenic Protein/Retinoic Acid Inducible Neural-Specific Protein; C6-C9; Complement components 6-9; CDC; cholesterol dependent cytolysin; EM; electron microscopy; fs; female sterile; IL-12; Interleukin-12; InR; Insulin-
Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia
Keywords: اسفنجی مینولیز اسید; Inflammasome; Ceramide; Acid sphingomyelinase; Atherosclerosis;
Increase in acid sphingomyelinase level in human retinal endothelial cells and CD34+ circulating angiogenic cells isolated from diabetic individuals is associated with dysfunctional retinal vasculature and vascular repair process in diabetes
Keywords: اسفنجی مینولیز اسید; Diabetic retinopathy; Acid sphingomyelinase; Circulating angiogenic cells; Revascularization;
Seven novel mutations of the SMPD1 gene in four Chinese patients with Niemann-Pick disease type A and prenatal diagnosis for four fetuses
Keywords: اسفنجی مینولیز اسید; Niemann-Pick disease type A (NPD-A); Acid sphingomyelinase; SMPD1 gene; Prenatal diagnosis
Riccardin D-N induces lysosomal membrane permeabilization by inhibiting acid sphingomyelinase and interfering with sphingomyelin metabolism in vivo
Keywords: اسفنجی مینولیز اسید; RD-N; Riccardin D-N; LMP; lysosomal membrane permeabilization; ASM; acid sphingomyelinase; SM; sphingomyelin; CADs; cationic amphiphilic drugs; LAMP1; lysosome associated membrane protein 1; PARP; poly (ADP-ribose) polymerase; LDH; lactate dehydrogenase;
Role of protein kinase C δ in apoptotic signaling of oxidized phospholipids in RAW 264.7 macrophages
Keywords: اسفنجی مینولیز اسید; Oxidized LDL; Atherosclerosis; Ceramide; Acid sphingomyelinase; Lipid-protein-interactions; Fluorescent phospholipids;
A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells
Keywords: اسفنجی مینولیز اسید; EOC; epithelial ovarian cancer; PTM; post-translational modification; GALNT3; N-acetylgalactosaminyltransferase 3; GalNAc-Ts; GalNAc-transferases; KD; knockdown; shRNA; short hairpin RNA; siRNA; small interfering RNA; MUC1; mucin-1; Ac4GalNAz; peraceetyla
Research ArticleSortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity
Keywords: اسفنجی مینولیز اسید; DIO; diet-induced obesity; aSMase; acid sphingomyelinase; NAFLD; non-alcoholic fatty liver disease; TGN; trans-Golgi network; TGs; triglycerides; LDL; low-density lipoprotein; GWAS; genome wide association studies; VPS10P; vacuolar protein sorting 10 prot
Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis
Keywords: اسفنجی مینولیز اسید; ASMase; acid sphingomyelinase; BMDMs; bone marrow-derived macrophages; C1P; ceramide 1-phosphate; M-CSF; macrophage colony stimulating factor; MTS; [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium, inner salt]; SP
Types A and B Niemann-Pick disease
Keywords: اسفنجی مینولیز اسید; Niemann-Pick; acid Sphingomyelinase; sphingomyelin; mouse model; enzyme replacement therapy;
ReviewAcid sphingomyelinase-ceramide system in steatohepatitis: A novel target regulating multiple pathways
Keywords: اسفنجی مینولیز اسید; ASH; alcoholic steatohepatitis; ASMase; acid sphingomyelinase; CtsB; cathepsin B; FA; free fatty acids; I/R; insulin resistance; Hcy; homocysteine; HCC; hepatocellular carcinoma; ER stress; endoplasmic reticulum stress; LMP; lysosomal membrane permeabiliz
Acid sphingomyelinase (aSMase) deficiency leads to abnormal microglia behavior and disturbed retinal function
Keywords: اسفنجی مینولیز اسید; Niemann-Pick disease; Acid sphingomyelinase; Microglia; Retina; Inflammation; Lipid accumulation;
Weakness, SR function and stress in gastrocnemius muscles of aged male rats
Keywords: اسفنجی مینولیز اسید; SR; sarcoplasmic reticulum; ER; endoplasmic reticulum; lo; optimal length; E-C coupling; excitation-contraction coupling; CSA; cross-sectional area; aSMase; acid sphingomyelinase; nSMase; neutral sphingomyelinase; SPT; serine palmitoyltransferase; GP;
Axitinib sensitization of high Single Dose Radiotherapy
Keywords: اسفنجی مینولیز اسید; Radiosurgery; Stereotactic body radiation therapy; Vascular endothelial growth factor; Acid sphingomyelinase; Ceramide; Anti-angiogenic;
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease
Keywords: اسفنجی مینولیز اسید; SL; sphingolipid; NAFLD; non-alcoholic fatty liver disease; HCV; hepatitis c virus; NASH; non-alcoholic steatohepatitis; ASM; acid sphingomyelinase; S1P; sphingosine1-phosphate; ALT; alanine aminotransferase; AST; aspartate aminotransferase; γGT; gamma-g
Research ArticleASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis
Keywords: اسفنجی مینولیز اسید; ASMase; acid sphingomyelinase; A-LDLR-DKO; ASMase/LDL receptor double knockout mice; CHQ; chloroquine; ER; endoplasmic reticulum; FFA; free fatty acids; GTT; glucose tolerance test; ITT; insulin tolerance test; IRβ; insulin receptor β subunit; HCD; high
The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells
Keywords: اسفنجی مینولیز اسید; PQ; paraquat; ROS; reactive oxygen species; Cu; copper; WD; Wilson disease; aSMase; acid sphingomyelinase; dhSph; dihydrosphingosine; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; DHE; dihydroethidium; TUNEL; terminal deoxynucleotidyl
Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation
Keywords: اسفنجی مینولیز اسید; AD; Alzheimer disease; Aβ; β-amyloid; APP; amyloid precursor protein; ASMase; acid sphingomyelinase; BACE; β-secretase β-site amyloid cleaving enzyme; BBB; blood-brain barrier; BCA; bicinchoninic acid; BHT; butylated hydroxytoluene; BSO; buthionine
Targeting (cellular) lysosomal acid ceramidase by B13: Design, synthesis and evaluation of novel DMG-B13 ester prodrugs
Keywords: اسفنجی مینولیز اسید; B13; (1R,2R)-2-(tetradecanoylamino)-1-(4â²-nitrophenyl)-1,3-propandiol; DMG; N,N-dimethyl glycine; LCL521; 1,3-O,O-DMG-B13 dihydrochloride; LCL522; 3-O-DMG-B13 hydrochloride; LCL596; 1-O-DMG-B13 hydrochloride; CX; stable mono-DMG-B13; ACDase; acid cerami
Effects of sphingomyelin/ceramide ratio on the permeability and microstructure of model stratum corneum lipid membranes
Keywords: اسفنجی مینولیز اسید; aSMase; acid sphingomyelinase; acylCer; Ï-O-acyl ceramide/s; Cer; ceramide/s; AD; atopic dermatitis; Chol; cholesterol from lanolin; FFA; free fatty acid/s; IND; indomethacin; HPTLC; high performance thin layer chromatography; hCer; ceramides of the huma
Human heat shock protein 70 (Hsp70) as a peripheral membrane protein
Keywords: اسفنجی مینولیز اسید; AcrA; acrylamide; aSM; acid sphingomyelinase; a.u.; arbitrary unit; BMP; bis(monoacylglycero)phosphate; Br2PC; brominated phosphatidylcholine; 6,7Br2-PC; 1-palmitoyl-2-(6,7-dibromo)stearoyl-sn-glycero-3-phosphocholine; 9,10Br2-PC; 1-palmitoyl-2-(9,10-dibr
Ceramide mediates lung fibrosis in cystic fibrosis
Keywords: اسفنجی مینولیز اسید; Ceramide; Cystic fibrosis; Acid sphingomyelinase; Cftr;
ReviewRole for membrane remodeling in cell death: Implication for health and disease
Keywords: اسفنجی مینولیز اسید; Aβ; amyloid-β-peptide; ALK; anaplastic lymphoma kinase; AMBRA; activating molecule in Beclin-1-regulated autophagy protein 1; ASM; acid sphingomyelinase; ATG; autophagy-related gene; B[a]P; benzo[a]pyrene; cav-1; caveolin-1; DCC; deleted in colorectal c
Combating apoptosis and multidrug resistant cancers by targeting lysosomes
Keywords: اسفنجی مینولیز اسید; Lysosome; Cell death; Multidrug resistance; Cathepsins; Acid sphingomyelinase