کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8264677 | 1534891 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Weakness, SR function and stress in gastrocnemius muscles of aged male rats
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کلمات کلیدی
E–C couplingnSMaseASMaseGRP78SPTAutophagy - اتوفاژیacid sphingomyelinase - اسفنجی مینولیز اسیدneutral sphingomyelinase - اسپینگومییلیناز خنثیCSA - ایالات مؤتلفهٔ آمریکاExcitation–contraction coupling - تحریک-انقباض جفت شدنSarcoplasmic reticulum - رتیکولوم سارکوپلاسمیکMyosin heavy chain - زنجیره سنگین میوزینceramide - سرامیدendoplasmic reticulum - شبکه آندوپلاسمی Optimal length - طول مطلوبMHC - مجموعه سازگاری بافتی اصلیcross-sectional area - مقطع عرضیParkin - پارکینSerine palmitoyltransferase - پریتیمویل ترانسفراز SerineCalcium - کلسیمSarcopenia - کم ماهیچگیGlycogen phosphorylase - گلیکوژن فسفریلاس
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Aging is associated with a decline in muscle force that exceeds loss of muscle mass, suggesting that factors other than sarcopenia affect age-related muscle weakness. Here, we investigate in situ muscle force and sarcoplasmic reticulum (SR) properties in gastrocnemius muscles of adult (6-8 months) and aged (24 months) rats. Despite minimal loss of muscle mass, peak tetanic force was significantly reduced (â 28%) in aged muscles. Adjusting for differences in muscle cross-sectional area mitigated the age difference (â 23%), but it remained significant. The SR calcium release function was also impaired (â 17%) with aging, although calcium uptake was not, and SR-associated glycogen increased (+ 30%) with aging. Western blotting revealed age related increases in Grp78, serinepalmitoyltransferase and neutral sphingomyelinase, suggesting that age increased the stress response and ceramide metabolism in the SR. In contrast Parkin, a protein associated with autophagic signaling, was reduced in the aged SR. These findings are consistent with a hypothesis that age-related impairments of the SR, possibly due to impaired autophagy and/or altered membrane metabolism, contribute to age-related muscle weakness, independent of changes in muscle mass.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Gerontology - Volume 50, February 2014, Pages 40-44
Journal: Experimental Gerontology - Volume 50, February 2014, Pages 40-44
نویسندگان
David W. Russ, Allison M. Wills, Iva M. Boyd, Jodi Krause,