کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8302337 | 1537728 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease
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کلمات کلیدی
γGTPKCδALTASMSupplementaryS1PDHCROCNAFLDAUC - AUCAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییHomeostatic model assessment - ارزیابی مدل هومستاتیکNon-alcoholic steatohepatitis - استئاتوهپاتیت غیرالکلیacid sphingomyelinase - اسفنجی مینولیز اسیدsphingosine - اسپینگوزینsphingolipid - اسپینگولایپیدnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیDihydroceramide - دی هیدروکرامیدceramide - سرامیدbody mass index - شاخص توده بدنBMI - شاخص توده بدنیLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)area under the curve - منطقه تحت منحنیNash - نوشHOMA - هومHepatitis C virus - هپاتیت سیHCV - هپاتیت سیprotein kinase Cδ - پروتئین کیناز Cδreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Sphingolipids constitute bioactive molecules with functional implications in homeostasis and pathogenesis of various diseases. However, the role of sphingolipids as possible disease biomarkers in chronic liver disease remains largely unexplored. In the present study we used mass spectrometry and spectrofluorometry methods in order to quantify various sphingolipid metabolites and also assess the activity of an important corresponding regulating enzyme in the serum of 72 healthy volunteers as compared to 69 patients with non-alcoholic fatty liver disease and 69 patients with chronic hepatitis C virus infection. Our results reveal a significant upregulation of acid sphingomyelinase in the serum of patients with chronic liver disease as compared to healthy individuals (p < 0.001). Especially in chronic hepatitis C infection acid sphingomyelinase activity correlated significantly with markers of hepatic injury (r = 0.312, p = 0.009) and showed a high discriminative power. Accumulation of various (dihydro-) ceramide species was identified in the serum of patients with non-alcoholic fatty liver disease (p < 0.001) and correlated significantly to cholesterol (r = 0.448, p < 0.001) but showed a significant accumulation in patients with normal cholesterol values as well (p < 0.001). Sphingosine, a further bioactive metabolite, was also upregulated in chronic liver disease (p < 0.001). However, no significant correlation to markers of hepatic injury was identified. Conclusion: Chronic hepatitis C virus infection and non-alcoholic fatty liver disease induce a significant upregulation of serum acid sphingomyelinase which appears as a novel biomarker in chronic hepatopathies. Further studies are required to elucidate the potential of the sphingolipid signaling pathway as putative therapeutic target in chronic liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 7, July 2014, Pages 1012-1020
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 7, July 2014, Pages 1012-1020
نویسندگان
Georgios Grammatikos, Christiane Mühle, Nerea Ferreiros, Sirkka Schroeter, Dimitra Bogdanou, Stephanie Schwalm, Gudrun Hintereder, Johannes Kornhuber, Stefan Zeuzem, Christoph Sarrazin, Josef Pfeilschifter,