کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8480048 | 1551369 | 2016 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipolytic and thermogenic depletion of adipose tissue in cancer cachexia
ترجمه فارسی عنوان
از بین بردن لیپولیتیک و ترموژنیک بافت چربی در سرطان سینه
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کلمات کلیدی
AMP activated kinaseSOCS3HSLPTHrPBATPRDM16SATIL-6G0S2AMPKSTAT3Janus kinase - کیناز جانوس Ucp1 - UCP1Atgl - اتگلAdipose tissue - بافت چربیvisceral adipose tissue - بافت چربی درشتsubcutaneous white adipose tissue - بافت چربی زیر جلدیWhite adipose tissue - بافت چربی سفیدThermogenesis - ترموژنزcomputed tomography - توموگرافی کامپیوتری یا سی تی اسکن یا مقطعنگاری رایانهایPR domain containing 16 - دامنه PR حاوی 16Type 2 diabetes mellitus - دیابت نوع دوCancer cachexia - سرطان cachexiasuppressor of cytokine signalling 3 - سرکوب سیگنالینگ سیتوکین 3adipose triglyceride lipase - لیپاز تری گلیسیرید چربیhormone sensitive lipase - لیپاز حساس به هورمونLipolysis - لیپولیزVAT - مالیات بر ارزش افزودهsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3Insulin resistance - مقاومت به انسولینuncoupling protein 1 - پروتئین جدا سازی 1Parathyroid hormone-related protein - پروتئین مرتبط با هورمون پاراتیروئیدbrown fat - چربی قهوه ایJAK - چگونهWAT - چیCidea - کید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Although muscle wasting is the obvious manifestation of cancer cachexia that impacts on patient quality of life, the loss of lipid reserves and metabolic imbalance in adipose tissue also contribute to the devastating impact of cachexia. Depletion of fat depots in cancer patients is more pronounced than loss of muscle and often precedes, or even occurs in the absence of, reduced lean body mass. Rapid mobilisation of triglycerides stored within adipocytes to supply the body with fatty acids in periods of high-energy demand is normally mediated through a well-defined process of lipolysis involving the lipases ATGL, HSL and MGL. Studies into how these lipases contribute to fat loss in cancer cachexia have revealed the prominent role for ATGL in initiating lipolysis during adipose tissue atrophy, together with links between tumour-derived factors and the signalling pathways that control lipid flux within fat cells. The recent findings of increased thermogenesis in brown fat during cancer cachexia indicate that metabolically active adipose tissue contributes to the imbalance in energy homeostasis involved in catabolic wasting. Such energetically futile use of fatty acids liberated from adipose tissue to generate heat represents a maladaptive response in conjunction with anorexia experienced by cancer patients. As IL-6 release by tumours provokes lipolysis and activates the thermogenic programme in brown fat, this review explores the overlap in dysregulated metabolic processes due to inflammatory mediators in cancer cachexia and other disease states characterised by elevated cytokines such as obesity and diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 54, June 2016, Pages 68-81
Journal: Seminars in Cell & Developmental Biology - Volume 54, June 2016, Pages 68-81
نویسندگان
Maria Tsoli, Michael M. Swarbrick, Graham R. Robertson,