Licensing of DNA replication, cancer, pluripotency and differentiation: An interlinked world?

- DNA replication, development, pluripotency and cancer share common regulatory nodes.
- Several pre-replicative machinery proteins have developmental roles.
- Deregulated expression of pre-RC members can induce carcinogenesis.
- Pluripotency-associated transcription factors influence DNA replication.
- Overexpression of pluripotency-associated transcription factors is linked to cancer.