کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8480764 | 1551393 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of spermatogenesis by small non-coding RNAs: Role of the germ granule
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کلمات کلیدی
IMCpiRNAsSSCGerm cellssiRNAsncRNAsRBPmiRNAsmRNPsGerm granulessncRNAsPIWIPGCssmall interfering RNAs - RNA های تداخل کوچکpiwi-interacting RNAs - RNA های تعامل می کنندnon-coding RNAs - RNA های غیر کدگذاریSmall non-coding RNAs - RNA های کوچک غیر کدگذاریArgonaute - آرگونوتSpermatogenesis - اسپرماتوژنزEpigenetics - اپی ژنتیکMvh - با احترامchromatoid body - بدن کروماتوئیدRISC - خطرmicroRNAs - ریز آرانایSpermatogonial stem cells - سلول های بنیادی اسپرماتوگونالیprimordial germ cells - سلول های بنیادی اولیهRNA-Induced Silencing Complex - مجتمع خاموش کننده RNA inducedPost-transcriptional regulation - مقررات پست مدرنRNA binding proteins - پروتئین های مرتبط با RNAAGO - پیش
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulation of spermatogenesis by small non-coding RNAs: Role of the germ granule Regulation of spermatogenesis by small non-coding RNAs: Role of the germ granule](/preview/png/8480764.png)
چکیده انگلیسی
The spermatogenic process relays in highly regulated gene expression mechanisms at the transcriptional and post-transcriptional levels to generate the male gamete that is needed for the perpetuation of the species. Small non-coding RNA pathways have been determined to participate in the post-transcriptional regulatory processes of germ cells. The most important sncRNA molecules that are critically involved in spermatogenesis belong to the miRNA and piRNAs pathways as illustrated by animal models where ablation of specific protein components displays male infertility. Several elements of these regulatory pathways have been found in the nuage or germ granule, a non-membranous cytoplasmatic structure that can be seen in spermatocytes and spermatids. This notion suggests that germ granules may act as organizer centers for silencing pathways in the germline. In general, miRNAs regulate spermatogenesis through targeting and down-regulation of specific transcripts to eventually promote sperm development. However, piRNAs are powerful repressors of transposon elements expression in the spermatogenic process. Here we describe the suggested functions that miRNA and piRNAs pathways execute in the regulation of spermatogenesis and include some recent studies in the field. Despite major strides on the detailed molecular mechanisms of sncRNAs in relation to spermatogenesis, there is plenty to discover on this fascinating regulatory program.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 29, May 2014, Pages 84-92
Journal: Seminars in Cell & Developmental Biology - Volume 29, May 2014, Pages 84-92
نویسندگان
Sara de Mateo, Paolo Sassone-Corsi,