دانلود مقالات ISI درباره Sirnas + ترجمه فارسی

بینش داروها و مکانیزم های بیماری های یبوست یبوست: وضعیت فعلی و انتظارات آینده

Insights into the pharmaceuticals and mechanisms of neurological orphan diseases: Current Status and future expectations

Keywords: ALS; Amyotrophic lateral sclerosis; DMD; DuchenneMuscular Dystrophy; SMA; Spinalmuscular atrophy; FAP; FamilialAmyloid Polyneuropathy; OD; Orphandisease; ORD; Officeof Rare Diseases; NIH; NationalInstitutes of Health; sALS; SporadicALS; fALS; FamilialALS;

دانلود رایگان متن کامل مقاله ISI 95 صفحه سال انتشار : 2018 سفارش ترجمه

سرنوشت سلول های عصبی در محیط آزمایشگاهی: دستاوردها و چالش ها

Directing neuronal cell fate in vitro: Achievements and challenges

Keywords: 5-HT; serotonin (5-hydroxytryptamine); A83-01; TGF-β kinase/activin receptor-like kinase inhibitor; ACTB; actin beta/beta-actin; ASCL1; achaete-scute homolog 1 (MASH1); ASOs; anti-sense oligonucleotides; Bcl-xL; b-cell lymphoma-extra large; BDNF; brain d

دانلود رایگان متن کامل مقاله ISI 131 صفحه سال انتشار : 2018 سفارش ترجمه

مسیر سیگنالینگ برای بیان آدیپونکتین در آدیپوسیتها توسط استئوکالسین

Signaling pathway for adiponectin expression in adipocytes by osteocalcin

Keywords: GluOC; uncarboxylated osteocalcin; GlaOC; γ-carboxylated osteocalcin; PKA; protein kinase A; ERK; extracellular signal-regulated kinase; PPAR; peroxisome proliferator-activated receptor; GLP-1; glucagon-like peptide-1; gWAT; gonadal white adipose tissue;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

منافذ انتقال نفوذی میتوکندری یک عنصر غیر ضروری برای خروج کلسیم میتوکندری است

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux

Keywords: ANT; adenine nucleotide translocase; [Ca2+]c; cytosolic calcium concentration; [Ca2+]m; mitochondrial calcium concentration; CsA; cyclosporine A; HK; hexokinase II; H2O2; hydrogen peroxide; IB; intracellular milieu; MCU; mitochondrial Ca2+ uniporter; NCLX

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

بیماری آلزایمر و رژیم غذایی اپی ژنتیک

Alzheimer's disease and epigenetic diet

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; AICD; APP intracellular domain; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APP; amyloid β precursor protein; Apo E; apolipoprotein E; BACE1; β-site APP converting enzyme 1; BDNF; brain derive

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2014 سفارش ترجمه

Phyto-miRNAs-based regulation of metabolites biosynthesis in medicinal plants

Keywords: Phyto-miRNAs; plant miRNAs; TM; target mimicry; RNAi; RNA interference; sncRNAs; non-coding RNAs; SiRNAs; short interfering RNAs; MiRNAs; microRNAs; Pre-miRNAs; precursor miRNAs; MRE; miRNA response element; PSMs; plant secondary metabolites; BIAs; benzyl

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2019 سفارش ترجمه

Upregulated long non-coding RNA SPRY4-IT1 predicts dismal prognosis for pancreatic ductal adenocarcinoma and regulates cell proliferation and apoptosis

Keywords: ATCC; American type culture collection; CCK-8; cell counting kit-8; HPDE; human pancreatic duct epithelial; IHC; immunohistochemistry; lncRNA; long non-coding RNA; PBS; phosphate-buffered saline; PDAC; pancreatic ductal adenocarcinoma; PI; propidium iodid

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Circular RNA Atp9b, a competing endogenous RNA, regulates the progression of osteoarthritis by targeting miR-138-5p

Keywords: OA; osteoarthritis; circRNAs; circular RNAs; ceRNAs; competing endogenous RNAs; miRNAs; microRNAs; IL-1β; interleukin-1β; ECM; extracellular matrix; GO; gene ontology; KEGG; Kyoto Encyclopedia of Genes and Genomes; qRT-PCR; quantitative real-time polyme

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

GDNF family receptor α-1 in the catfish: Possible implication to brain dopaminergic activity

Keywords: aa; amino acid; CA; catecholamines; cfGnRH; catfish gonadotropin regulating hormone; cyp19a1; aromatase; Cont; control; DA-ergic; dopaminergic; DIG; digoxigenin; Dph; days post hatch; E2; estradiol-17β; ER; E2 receptor; F; female; GDNF; Glial cell line-d

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

WISP-3/CCN6 inhibits apoptosis by regulating caspase pathway after hyperoxia in lung epithelial cells

Keywords: Flot-2; Flotillin-2; ALI; acute lung injury; ICUs; intensive care units; ARDS; acute respiratory distress syndrome; HALI; hyperoxia induced acute lung injury; Cytc; Cytochrome c; WISP3; Wnt1-inducible signaling protein-3; siRNAs; small interfering RNAs; N

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Relationship between OPA1 and cardiolipin in mitochondrial inner-membrane fusion

Keywords: OPA1; optic atrophy 1; IM; inner membrane; OM; outer membrane; CL; cardiolipin; KO; knockout; Mfns; mitofusins; MEF; mouse embryonic fibroblast; mtDNA; mitochondrial DNA; Drp1; dynamin-related protein 1; Mff; mitochondrial fission factor; MiD49/MIEF2; mit

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Small RNA differential expression and regulation in Tuxpeño maize embryogenic callus induction and establishment

Keywords: Maize; miRNAs; siRNAs; Somatic embryogenesis; Transposable elements;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Mixomics analysis of breast cancer: Long non-coding RNA linc01561 acts as ceRNA involved in the progression of breast cancer

Keywords: lncRNA; long non-coding RNA; BrCa; breast cancer; miRNAs; microRNAs; ceRNAs; competing endogenous RNAs; MMP11; Matrix metallopeptidase 11; DEGs; differentially expressed genes; SPLSDA; Stacked Partial Least-Squares Discriminant Analysis; FBS; Fetal Bovine

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Engineered exosomes: A new promise for the management of musculoskeletal diseases

Keywords: Engineered exosomes; Drug delivery; Musculoskeletal diseases; Regenerative medicine; Oncology; Immune system regulation; 3′UTR; 3′untranslated regions; 6-OHDA; 6-hydroxydopamine; APC; adenomatous polyposis coli; BRD7; bromo-domain-containing protein 7

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Piwil1 gene is regulated by hypothalamic-pituitary-gonadal axis in turbot (Scophthalmus maximus): A different effect in ovaries and testes

Keywords: HPG axis; hypothalamic-pituitary-gonadal axis; hCG; human chorionic gonadotropin; E2; estradiol-17β; MT; 17α-methyltestosterone; snRNAs; small non-coding RNAs (snRNAs); miRNAs; microRNAs; piRNAs; Piwi-interacting RNAs; siRNAs; small interfering RNAs; Gn

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Analyses of long non-coding RNAs and mRNA profiling through RNA sequencing of MDBK cells at different stages of bovine viral diarrhea virus infection

Keywords: BVDV; Bovine viral diarrhea virus; CNCI; Coding-Non-Coding-Index; CPC; Coding Potential Calculator; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; FPKMs; fragments per kilobase of transcript sequences per million base pairs sequenced;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Engineering approaches in siRNA delivery

Keywords: siRNAs; Delivery vectors; in vitro models; Mathematical modeling; Physical modeling;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Structural Foundations of RNA Silencing by Argonaute

Keywords: Argonaute; RNA-induced silencing complex; RNA silencing; microRNA; RISC; RNA-induced silencing complex; miRNAs; microRNAs; siRNAs; small interfering RNAs; RNAi; RNA interference; piRNAs; Piwi-interacting RNAs; RLC; RISC-loading complex; RNase H; ribonucle

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

LncRNA-ATB/microRNA-200a/β-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis

Keywords: 3′-UTR; 3′-untranslated region; α-SMA; α-smooth muscle actin; ceRNA; competing endogenous RNA; CM; conditioned media; Col1A1; alpha-1 type I collagen; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; HCV; hepatitis C virus; HCC; he

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Long noncoding RNAs: Unexplored players in the drug response of the sea louse Caligus rogercresseyi

Keywords: lncRNAs; long non-coding RNAs; GC; guanine-cytosine; ncRNAs; non-coding RNAs; miRNAs; microRNAs; siRNAs; small interfering RNAs; piRNAs; PIWI-interacting RNAs; MFE; minimum free energy; RPKM; transcript as reads per kilobase of exon model per million mapp

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

LTR-retrotransposons in plants: Engines of evolution

Keywords: AoPR1; Asparagus officinalis pathogenesis-related 1; Aox; alternate oxidase; Cf2/9; Cladosporium fulvum resistance gene; ERF1; ethylene response factor 1; ERPB/AP2; ethylene-responsive element binding protein/Apetala2; ETI; Effector-Triggered Immunity; HR

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Role of small RNAs in abiotic stress responses in plants

Keywords: miRNAs; siRNAs; Abiotic stress; Stress response; sRNAs;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

A cytometry microparticle platform approach for screening tobacco microRNA changes after agrobacterium delivery

Keywords: EF1α; elongation factor 1-alpha; gfp; green fluorescent protein; GP1; glycoprotein 1; LB; Luria broth; miRNA; micro-RNA; mRNA; messenger RNA; NGS; Next-generation sequencing; PAMPs; pathogen-associated molecular patterns; qRT-PCR; quantitative real-time

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Conserved sequences in the current strains of HIV-1 subtype A in Russia are effectively targeted by artificial RNAi in vitro

Keywords: RT, reverse transcriptase domain; int, integrase domain; Pol, domain specifying protease, reverse transcriptase, RNase and integrase in HIV-1; A1–A3, about 300-bp regions of pol-domain containing the targets of RNAiHIV-1 in Russia; Subtype A; RNAi; siRNAs

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

HC-Pro viral suppressor from tobacco vein banding mosaic virus interferes with DNA methylation and activates the salicylic acid pathway

Keywords: RNA silencing suppressor; Tobacco vein banding mosaic virus; HC-Pro; SiRNAs;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Sodium valproate prevents radiation-induced injury in hippocampal neurons via activation of the Nrf2/HO-1 pathway

Keywords: BW; body weight; GSH; glutathione; GSK3; glucose synthase kinase-3; HDAC; histone deacetylase; HO-1; heme oxygenase-1; MDA; malondialdehyde; ROS; reactive oxygen species; siRNAs; short interfering RNAs; SOD; superoxide dismutase; sodium valproate; ionizin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Non-coding RNAs in gastric cancer

Keywords: ncRNAs; non-coding RNAs; sncRNAs; small ncRNAs; lncRNAs; long ncRNAs; snoRNAs; small nucleolar RNAs; piRNAs; Piwi-associated RNAs; miRNAs; microRNAs; tiRNAs; transcription initiation RNAs; lincRNAs; long intergenic ncRNAs; GC; gastric cancer; nts; nucleot

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Neuroprotective action of raloxifene against hypoxia-induced damage in mouse hippocampal cells depends on ERα but not ERβ or GPR30 signalling

Keywords: SERMs; Apoptosis; siRNAs; Immunoblots; Primary neuronal cell culturesAc-DEVD-pNA, N-acetyl-asp-glu-val-asp p-nitro-anilide; CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate hydrate; CO2, carbon dioxide; DIV, day in vitro; DMSO, dimethyl su

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Delivery of therapeutic oligonucleotides with cell penetrating peptides

Keywords: Cell penetrating peptides; Delivery; Antisense oligonucleotides; Splice switching oligonucleotides; siRNAs;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2015 سفارش ترجمه

Detection of immune response activation by exogenous nucleic acids by a multiplex RT-PCR method

Keywords: Immune response detection; Interferon; Multiplex RT-PCR; CpG DNA oligonucleotide; siRNAs; Toll-like receptors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

ERK2 small interfering RNAs prevent epidural fibrosis via the efficient inhibition of collagen expression and inflammation in laminectomy rats

Keywords: FBSS; failed back surgery syndrome; EF; epidural fibrosis; RNAi; RNA interference; ERK2; extra-cellular signal-regulated kinase 2; siRNAs; small interfering RNAs; TGF-β1; transforming growth factor-β1; IL6; interleukin 6; GFP; green fluorescent protein;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleMicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity

Keywords: EZH2; enhancer of zeste homolog 2; miR-101; microRNA-101; HCC; hepatocellular carcinoma; miRNA(s); microRNA(s); mRNA(s); messenger RNA(s); Mcl-1; myeloid cell leukemia sequence 1; siRNAs; small interfering RNAs; qPCR; quantitative real-time PCR; UTR; untr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Regulation of spermatogenesis by small non-coding RNAs: Role of the germ granule

Keywords: Epigenetics; Germ cells; Germ granules; miRNAs; piRNAs; Post-transcriptional regulation; sncRNAs; Spermatogenesis; RBP, RNA binding proteins; Ago; Argonaute; CB; Chromatoid body; IMC; Intermitochondiral cement; miRNAs; microRNAs; mRNPs; Mrna ribonucleopro

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma

Keywords: CENPF; centromere protein F; HCC; hepatocellular carcinoma; CHD1L; chromodomain helicase DNA binding protein 1-like; JTB; jumping translocation breakpoint; SHC1; Src homology 2 domain containing transforming protein 1; MAD1; mitotic arrest deficient-like

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Transcriptional evidence for small RNA regulation of pupal diapause in the flesh fly, Sarcophaga bullata

Keywords: Phenotypic plasticity; Maternal effect; miRNA; piRNAs; siRNAs;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Research ArticleDeep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma

Keywords: ncRNA; non-coding RNA; miRNA; microRNA; HCC; hepatocellular carcinoma; piRNA; PIWI-interacting RNA, snoRNAs, small nucleolar RNAs; siRNAs; small interfering RNAs; qRT-PCR; quantitative reverse transcription-polymerase chain reaction; CUHK-NTEC; Chinese Un

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Small RNAs were involved in homozygous state-associated silencing of a marker gene (Neomycin phosphotransferase II: nptII) in transgenic tomato plants

Keywords: nptII gene; Small RNAs; Homozygous state-associated silencing; Post-transcriptional gene silence; Tomato; CaMV; cauliflower mosaic virus; CHS; chalcone synthase; dsRNAs; double stranded RNAs; hpRNA; hairpin RNA; IR; inverted repeats; PTGS; post-transcript

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Progestin drives breast cancer growth by inducing p21CIP1 expression through the assembly of a transcriptional complex among Stat3, progesterone receptor and ErbB-2

Keywords: PR; progesterone receptor; MPA; medroxy progesterone acetate; CdK; cyclin dependent kinase; PREs; progesterone response elements; Stat3; signal transducer and activator of transcription 3; GAS; gamma interferon-activated sequence; siRNAs; small interferen

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of hepatitis B virus replication in cultured cells and in vivo using 2′-O-guanidinopropyl modified siRNAs

Keywords: HBV; RNAi; siRNAs; 2′-O-Guanidinopropyl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Disruption of the p53-p21 pathway inhibits efficiency of the lytic-replication cycle of herpes simplex virus type 2 (HSV-2)

Keywords: HSV-2; Viral replication; p53; p21; siRNAs;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

MEK1-ERKs signal cascade is required for the replication of Enterovirus 71 (EV71)

Keywords: EV71; Viral replication cycle; MEK1; MEK2; ERK; siRNAs;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

PnPMA1, an atypical plasma membrane H+-ATPase, is required for zoospore development in Phytophthora parasitica

Keywords: Development; Plasma membrane H+-ATPase; siRNAs; Topology; Zoospore motility; Zoosporogenesis;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Hepatitis C virus entry: Role of host and viral factors

Keywords: E1, E2; Envelop proteins 1, 2; HCC; Hepatocellular carcinoma; HCV; Hepatitis C virus; CD81; Cluster of differentiation 81; SR-BI; Scavenger receptor class B Type I; LDL-R; Low-density lipoprotein receptor; CLDN 1; Claudin 1; PEG-INF-α; pegylated interfer

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Genome-wide identification of Dicer-like, Argonaute and RNA-dependent RNA polymerase gene families and their expression analyses in response to viral infection and abiotic stresses in Solanum lycopersicum

Keywords: AGO; Argonaute; CS; chilling stress; CDS; coding DNA sequence; CK; control; DCL; Dicer-like protein; dsRNAs; double-stranded RNAs; DS; drought stress; HS; heat stress; hc-siRNAs; heterochromatic siRNAs; ITAG; International Tomato Annotation Group; miRNAs;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of E2F1–cyclin E1–E2 circuit down regulation in hepatocellular carcinoma cells

Keywords: Cell cycle gene depletion; Cell proliferation; siRNAs

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

The multiple roles of amphiregulin in human cancer

Keywords: AREG; amphiregulin; TACE; tumor-necrosis factor-alpha converting enzyme; ADAM; a disintegrin and metalloproteinase; CTF; carboxy-terminal fragment; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFR-TKI; epidermal growth factor rec

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Oocyte-somatic cell communication and microRNA function in the ovary

Keywords: MicroARN; siARN; Folliculogenèse ovarienneMicroRNAs; siRNAs; Ovarian folliculogenesis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Serum response factor depletion affects the proliferation of the hepatocellular carcinoma cells HepG2 and JHH6

Keywords: SRF; HCC; siRNAs

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Liposome–polyethylenimine complexes for enhanced DNA and siRNA delivery

Keywords: Liposomes; Gene delivery; RNAi; siRNAs; Polyethylenimine; Lipid coating

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Inwardly rectifying potassium channel Kir4.1 is responsible for the native inward potassium conductance of satellite glial cells in sensory ganglia

Keywords: trigeminal ganglia; dorsal root ganglia; KCNJ10; potassium channel; potassium buffering; pain; CNS; central nervous system; EGFP; enhanced green fluorescent protein; EGTA; ethylene glycol tetraacetic acid; GLAST; glutamate-aspartate transporter; GS; gluta

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه