کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8497547 1553509 2018 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absence of protection from West Nile virus disease and adverse effects in red legged partridges after non-structural NS1 protein administration
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Absence of protection from West Nile virus disease and adverse effects in red legged partridges after non-structural NS1 protein administration
چکیده انگلیسی
The red-legged partridge (Alectoris rufa) is a competent host for West Nile virus (WNV) replication and highly susceptible to WNV disease. With the aim to assess in this species whether the inoculation of non-structural protein NS1 from WNV elicits a protective immune response against WNV infection, groups of partridges were inoculated with recombinant NS1 (NS1 group) or an unrelated recombinant protein (mock group), and challenged with infectious WNV. A third group received no inoculation prior to challenge (challenge group). The NS1 group failed to elicit detectable antibodies to NS1 while in the mock group a specific antibody response was observed. Moreover, no protection against WNV disease was observed in the NS1 group, but rather, it showed significantly higher viral RNA load and delayed neutralizing antibody response, and suffered a more severe clinical disease, which resulted in higher mortality. This adverse effect has not been observed before and warrants further investigations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Immunology, Microbiology and Infectious Diseases - Volume 56, February 2018, Pages 30-33
نویسندگان
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