کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8503878 | 1554292 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aflatoxin B1 induced renal and cardiac damage in rats: Protective effect of lycopene
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
This study was conducted to investigate the protective effects of lycopene against the toxic effects of Aflatoxin B1 (AFB1) exposure in kidney and heart of rat by evaluating antioxidant defense systems and lipid peroxidation (LPO). Forty-two healthy three-month-old male Wistar-Albino rats were used in this study. The animals were randomly divided into six experimental groups including 7 rats in each. These groups were arranged as follows: control group, lycopene (5â¯mg/kg/day, orally for 15â¯days) group, AFB1 (0.5â¯mg/kg/day, orally for 7â¯days) group, AFB1 (1.5â¯mg/kg/day, orally for 3â¯days) group, AFB1 (0.5â¯mg/kg/day, orally for 7â¯days)â¯+â¯lycopene (5â¯mg/kg/day, orally for 15â¯days) group and AFB1 (1.5â¯mg/kg/day, orally for 3â¯days)â¯+â¯lycopene (5â¯mg/kg/day, orally for 15â¯days) group. The animals were sacrificed at the end of applications. In this study, malondialdehyde (MDA) levels significantly increased; while reduced glutathione (GSH), glutathione-S-transferase (GST), catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glucose-6-phosphate-dehydrogenase (G6PD) activities decreased in kidney and heart tissues. The significant reduction in the activities of antioxidant enzymes and non-enzymatic antioxidant system in AF treated rats as compared to the control group could be responsible for increased MDA levels observed during AF induced kidney and heart damage. The results showed increased urea, creatinine levels, as well as reduction sodium concentrations in plasma of AFB1 treated rats. There was lycopene showed protection against AF induced nephrotoxicity and cardiotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 119, August 2018, Pages 268-275
Journal: Research in Veterinary Science - Volume 119, August 2018, Pages 268-275
نویسندگان
Seval Yilmaz, Emre Kaya, Aysegul Karaca, Ozhan Karatas,