کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8503896 | 1554292 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles Investigation into the genetic diversity in toll-like receptors 2 and 4 in the European badger Meles meles](/preview/png/8503896.png)
چکیده انگلیسی
The Toll-like receptor (TLR) genes are a conserved family of genes central to the innate immune response to pathogen infection. They encode receptor proteins, recognise pathogen associated molecular patterns (PAMPs) and trigger initial immune responses. In some host-pathogen systems, it is reported that genetic differences, such as single nucleotide polymorphisms (SNPs), associate with disease resistance or susceptibility. Little is known about TLR gene diversity in the European badger (Meles meles). We collected DNA from UK badgers, carried out PCR amplification of the badger TLR2 gene and exon 3 of TLR4 and determined DNA sequences for individual badgers for TLR2 (nâ¯=â¯61) and TLR4 exon 3 (nâ¯=â¯59). No polymorphism was observed in TLR4. Three TLR2 amino acid haplotype variants were found. Ninety five percent of badgers were homozygous for one common haplotype (H1), the remaining three badgers had genotypes H1/H3, H1/H2 and H2/H2. By broad comparison with other species, diversity in TLR genes in badgers seems low. This could be due to a relatively localised sampling or inherent low genetic diversity. Further studies are required to assess the generality of the low observed diversity and the relevance to the immunological status of badgers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 119, August 2018, Pages 228-231
Journal: Research in Veterinary Science - Volume 119, August 2018, Pages 228-231
نویسندگان
Andrew M. Whiteoak, Justin Ideozu, Hadil Alkathiry, Alexandra J. Tomlinson, Richard J. Delahay, Sara Cowen, Elizabeth Mullineaux, Eamonn Gormley, Richard J. Birtles, Zhao-Rong Lun, Geoff Hide,