کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8506072 | 1555623 | 2018 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of an antiparasitic compound extracted from Polygonum cuspidatum against Ichthyophthirius multifiliis in grass carp
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ichthyophthirius multifiliis is a ciliated parasite that infests almost all freshwater fish species and causes great economic losses to the aquaculture industry. In this study, a compound with anti-I. multifiliis activity was isolated from Polygonum cuspidatum and identified as emodin. In vitro anti-I. multifiliis results showed that emodin at 1â¯mg/L killed all I. multifiliis theronts for 96.0â¯min, and at 0.5â¯mg/L or lower concentrations could not kill all I. multifiliis theronts, but could significantly reduce the infectivity of theronts after pretreatment with emodin at the low concentrations mentioned above for 2â¯h. Additionally, emodin at 1â¯mg/L and 2â¯mg/L completely terminated the reproduction of nonencysted and encysted tomonts, respectively. In vivo tests, emodin at 0.5â¯mg/L could cure infected grass carp and protect naive fish from I. multifiliis infection by continuous adding emodin for 10 days. The 96â¯h median lethal concentration (LC50) of emodin to grass carp was 3.15â¯mg/L, which were approximately 18 and 7 times the median effective concentration (EC50) of emodin for killing theronts (0.18â¯mg/L) and nonencysted tomonts (0.45â¯mg/L), respectively. On the basis of these results, emodin is an effective compound for the development of a new drug against I. multifiliis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Veterinary Parasitology - Volume 253, 15 April 2018, Pages 22-25
Journal: Veterinary Parasitology - Volume 253, 15 April 2018, Pages 22-25
نویسندگان
Sheng-Yu Zhou, Yan-Meng Liu, Qi-Zhong Zhang, Yao-Wu Fu, De-Jie Lin,