The effect of Coenzyme Q10 supplementation on serum levels of lactate, pyruvate, matrix metalloproteinase 9 and nitric oxide in women with migraine. A double blind, placebo, controlled randomized clinical trial

In the current trial, 12 weeks of oral CoQ10 supplementation demonstrated positive effects on control of migraine attacks, mitochondrial function, serum levels of NO and MMP-9 as an involvement factors in the pathophysiology of migraines.