کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8516093 1556535 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Betacaryophyllene - A phytocannabinoid as potential therapeutic modality for human sepsis?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Betacaryophyllene - A phytocannabinoid as potential therapeutic modality for human sepsis?
چکیده انگلیسی
Sepsis is a clinical condition resulting from a dysregulated immune response to an infection that leads to organ dysfunction. Despite numerous efforts to optimize treatment, sepsis remains to be the main cause of death in most intensive care units. The endogenous cannabinoid system (ECS) plays an important role in inflammation. Cannabinoid receptor 2 (CB2R) activation is immunosuppressive, which might be beneficial during the hyper-inflammatory phase of sepsis. Beta-caryophyllene (BCP) is a non-psychoactive natural cannabinoid (phytocannabinoid) found in Cannabis sativa and in essential oils of spices and food plants, that acts as a selective agonist of CB2R. We propose BCP administration as novel treatment to reduce hyper-inflammation in human sepsis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Hypotheses - Volume 110, January 2018, Pages 68-70
نویسندگان
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