Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs

From a series of separation, we got different fractions of rosemary, among which, petroleum ester fraction exhibited the best activity on SREBP inhibition. In cell culture and diet-induced obese mice, petroleum ester fraction of rosemary (PER) down-regulates SREBP target genes, reduced lipid content, and improved insulin sensitivity.