Keywords: ACC1; acetylcoenzyme A carboxylase 1; ASIP; agouti signaling protein; BETA2; transcription factor Beta 2; CYP7a1; cytochrome P450, family 7, subfamily a, polypeptide 1; cFOS; transcription factor C-fos; FASN; fatty acid synthase; FOXA2; forkhead box prote
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Keywords: Sirt1; Sirtuin 1; SREBPs; Sterol regulatory element binding proteins; AMPK; AMP-activated protein kinase; ACC; Acetyl-CoA carboxylase; Fas; Fatty acid synthase; Nampt; Nicotinamide phosphoribosyltransferase; LKB1; Liver kinase B1; ER; Endoplasmic reticulu
Keywords: ACLY; ACC; SREBPs; AMPK; ATGL; Lipa;
Keywords: ABCA1; ATP-binding cassette sub-family A member 1; AD; Alzheimer's disease; apoB48; apolipoprotein B-48; APP; amyloid precursor protein; BCMO1; β-carotene 15,15â²-monooxygenase; BLAOA; bovine α-lactalbumin complexed with oleic acid; CD36; cluster of di
Keywords: 1,25(OH)2D; 1,25 dihydroxy vitamin D (calcitriol); 3βHSD; 3β-hydroxysteroid dehydrogenase; ACAT; acyl transferase; ACTH; adrenocorticotropic hormone; ANT; adenine nucleotide transporter; ER; endoplasmic reticulum; CRAC; cholesterol recognition amino aci
Roles of microRNA in prostate cancer cell metabolism
Keywords: AMPK; adenosine monophosphate-activated protein kinase; HIF-1α; hypoxia-inducible factor 1-alpha; mTOR; mammalian target of rapamycin; PI3K/AKT; phosphatidylinositol 3-kinase; ATP; adenosine triphosphate; TCA cycle; tricarboxylic acid cycle; GLUTs; gluco
Fish oil and fenofibrate inhibit pancreatic islet hypertrophy, and improve glucose and lipid metabolic dysfuntions with different ways in diabetic KK mice
Keywords: ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; AOX; acyl-CoA oxidase; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; FAS; fatty acid synthase; FF; fenofibrate; FO; fish oil; H&E; haematoxylin eosin; HO
Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway
Keywords: Ganoderic Acid A; SREBPs; Obesity; Insulin resistance; Lipid accumulation; ABCA1; ATP-binding cassette transporter 1; ACC; acetyl-CoA carboxylase; ACO; acyl-CoA oxidase; BAT; brown adipose tissue; CPT1; carntine palmitoyltransferase 1; CYP7A1; cholesterol
A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet
Keywords: 3â²UTRs; 3â² untranslated regions; Acad1; Acyl-coenzyme A dehydrogenase 1; Acox1; Acyl-coenzyme A oxidase 1; ASO; anti-sense oligonucleotide; ChIP; chromatin immunoprecipitation; Cpt1a; Carnitine palmitoyltransferase 1A; FAO; fatty acid oxidation; Fasn;
DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance
Keywords: Endoplasmic reticulum; Epigenetics; Obesity; Triglycerides; Insulin resistance; BMI; body mass index; CASP12; caspase 12; CpG; cytosine-phosphate-guanine site; DBP; diastolic blood pressure; DiOGenes; diet obesity and genes dietary trial; DNAJC1; dnaJ hea
Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic
Keywords: Obesity; Chronic low-grade inflammation; Pharmacotherapy; Novel targets; Medicinal plants; Clinical studies; Contents; 5HT2CR; Serotonin receptors subtype 2C; ACC; Acetyl-CoA carboxylase (EC 6.4.1.2); ACTH; Adrenocorticotropic hormone; AgRP; Agouti-relate
Anti-hyperlipidemic effects of Rhizoma Coptidis alkaloids are achieved through modulation of the enterohepatic circulation of bile acids and cross-talk between the gut microbiota and the liver
Keywords: ASBT; apical sodium-dependent bile salt transporter; BSEP; bile salt export pump; COX2; cyclooxygenase 2; CYP7A1; cholesterol 7α-hydroxylase; FXR; farnesoid X receptor; HFHC; high fat and high cholesterol; HMGCR; 3-hydroxy-3-methyl glutaryl coenzyme A re
Carnosic acid alleviates hyperlipidemia and insulin resistance by promoting the degradation of SREBPs via the 26S proteasome
Keywords: CA; carnosic acid; SREBPs; sterol regulatory element-binding proteins; pre-SREBPs; precursor SREBPs; n-SREBPs; nucleus SREBPs; WD; western type diet; NCD; normal chow diet; 24-HC; 24-hydroxycholesterol; 25-HC; 25-hydroxycholesterol; 27-HC; 27-hydroxychole
Osteogenesis imperfecta: new genes reveal novel mechanisms in bone dysplasia
Keywords: ADAMTS; A disintegrin and metalloprotease with thrombospondin motifs; AR-OI; autosomal recessive osteogenesis imperfecta; ATF6; activating transcription factor 6; ATGL; adipose triglyceride lipase; BiP; binding immunoglobulin protein; BMDD; bone mineraliz
PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs
Keywords: Hepatitis C virus (HCV); HCV RNA translation modulation; PI3K; Akt isoforms; SREBPs; NS5A;
Petroleum ether sub-fraction of rosemary extract improves hyperlipidemia and insulin resistance by inhibiting SREBPs
Keywords: Rosemary; SREBPs; Hyperlipidemia; Insulin resistance;
Acute effects of oral olanzapine treatment on the expression of fatty acid and cholesterol metabolism-related gene in rats
Keywords: Olanzapine; Pharmacokinetics; Dyslipidemia; SREBPs
RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form
Keywords: CTR; control; CRISPR; clustered regularly interspaced short palindromic repeats; EDTA; ethylenediaminetetraacetic acid; FBS; fetal bovine serum; HPRT; hypoxanthine-guanine phosphoribosyltransferase; LDL-C; low-density lipoprotein cholesterol; LDLR; low-de
Targeting SREBPs for treatment of the metabolic syndrome
Keywords: metabolic syndrome; insulin resistance; SREBPs; SREBP inhibitors
HDL and cognition in neurodegenerative disorders
Keywords: ABC; ATP-binding cassette transporter; AD; Alzheimer's disease; Akt; protein kinase B; ALS; amyotrophic lateral sclerosis; apo; apolipoprotein; Aβ; amyloid-β protein; BBB; blood-brain barrier; CAA; cerebral amyloid angiopathy; CE; cholesterol ester; C
The hypocholesterolemic activity of açaà (Euterpe oleracea Mart.) is mediated by the enhanced expression of the ATP-binding cassette, subfamily G transporters 5 and 8 and low-density lipoprotein receptor genes in the rat
Keywords: Euterpe oleracea Martius; AçaÃ; Hypercholesterolemia; Expression of genes of cholesterol metabolism; Rats; ABCGs; ATP-binding cassette subfamily G transporters; ANOVA; analysis of variance; ApoB100; apolipoprotein B100; C; control group; CA; control sup
Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat diet
Keywords: Carnosine; Histidine; Steatosis; SREBPs; Insulin;
Piperidine alkaloids from Piperretrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase
Keywords: AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; SREBPs; sterol regulatory element-binding proteins; FAS; fatty acid synthase; CPT; carnitine palmitoyltransferase; UCP; uncoupling protein; PPAR; peroxisome proliferator-activated receptor;
Circadian rhythm of cholesterol synthesis in mouse liver: A statistical analysis of the post-squalene metabolites in wild-type and Crem-knock-out mice
Keywords: CREM; cAMP response element modulator; DHL; 24,25-dihydrolanosterol; T-MAS; testis meiosis-activating sterol; 7-DHC; 7-dehydrocholesterol; CYP51; lanosterol-14α-demethylase; SREBPs; sterol regulatory-element-binding proteins; ICER; inducible cAMP early r
Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1
Keywords: ACC; acetyl-CoA carboxylase; ADRP; adipose differentiation-related protein; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ApoB; apolipoprotein B; FAS; fatty acid synthase; GAPDH; glyceraldehyde-3-phosphate dehyd
Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes
Keywords: Cholesterol and lipids metabolism; HMG-CoA reductase; Bile acid synthesis; Acetyl CoA carboxylase-1; Fatty acid synthase; SREBPs; Mitochondria; 5-Cholesten-3β; 25-Diol 3-sulfate
Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease
Keywords: SREBPs; cholesterol; triglycerides; nephropathy; glomerular basement membrane thickness; podocyte width