کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8530895 | 1559727 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Shikimic acid prevents cartilage matrix destruction in human chondrocytes
ترجمه فارسی عنوان
اسید شیکیمیک از تخریب ماتریس غضروف در کانادایی های انسانی جلوگیری می کند
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Abnormal reduction of extracellular matrix (ECM), including type II collagen and aggrecan, caused by tumor necrosis factor-α (TNF-α) is an important pathological feature of osteoarthritis (OA). Shikimic acid (SA), derived from natural plants, has displayed effective pharmacological properties in diverse diseases. The biological roles of SA in OA have not been reported before. Here, we found that treatment with SA (1â¯mM, 10â¯mM) prevented TNF-α-induced degradation of type II collagen and aggrecan ECM in human primary chondrocytes culture in vitro. Importantly, we also reported that SA treatment reduced TNF-α-induced expression of matrix metalloproteinaseâ1, â3, and â13 (MMPâ1, â3, and â13) and increased expression of tissue inhibitor of metalloproteinaseâ1 and â2 (TIMPâ1, â2). Additionally, SA treatment attenuated TNF-α-induced expression of a disintegrin and metalloproteaseâ4 and â5 (ADAMTSâ4, â5). Mechanistically, we found that SA prevented activation of the nuclear factor-κB (NFâκB) pathway. Our findings suggest that SA might act as an important therapeutic agent in the treatment of OA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 63, October 2018, Pages 155-160
Journal: International Immunopharmacology - Volume 63, October 2018, Pages 155-160
نویسندگان
Xiaobin Guo, Liangliang Wang, Menglei Xu, Jiaxiang Bai, Jining Shen, Binqing Yu, Yu Liu, Houyi Sun, Yuefeng Hao, Dechun Geng,