کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8532942 | 1560449 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Systems pharmacology dissection of the anti-stroke mechanism for the Chinese traditional medicine Xing-Nao-Jing
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کلمات کلیدی
HIFPPI networkHIF1αrtPASH2NSPCHCsCXCL2RAC-alpha serine/threonine-protein kinase - RAC-alpha serine / ترئونین-پروتئین کینازSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNAAkt - آکتinterleukin-6 - اینترلوکین ۶Oxidative stress - تنش اکسیداتیوKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوSea - دریاییCNS - دستگاه عصبی مرکزیBBB - سد خونی مغزیNeural stem and progenitor cells - سلول های ساقه عضلانی و پیش سازStroke - سکته مغزیcentral nervous system - سیستم عصبی مرکزیProtein–protein interaction network - شبکه متقابل پروتئین-پروتئینIL 6 - ششمSystems pharmacology - فارماکولوژی سیستمHypoxia-inducible factor - فاکتور القاء کننده هیپوکسیRecombinant tissue plasminogen activator - فعال کننده پلاسمینوژن بافت بازمیگرددdrug-likeness - مواد مخدرHigh content screening - نمایش محتویات بالا
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Xing-Nao-Jing (XNJ) is a well-known injection that has been extensively applied in clinical treatment of stroke in China. However, the underlying mechanism of clinical administration of XNJ in stroke remains unclear. In this study, a systems pharmacology strategy based on pharmacokinetic and pharmacodynamics data was applied to analyze the pharmacological effect of XNJ on stroke. Sixteen active compounds were filtered from XNJ through Drug-likeness (DL) and Brain-blood-barrier (BBB) evaluations. Ninety-four potential targets of these active components were identified by SysDT and SEA. Biological process and pathway enrichment analyses of these targets demonstrated that XNJ exerted anti-stroke effects by biological processes and pathways, such as the response to oxidative stress, regulation of blood pressure, calcium signaling pathway, and apoptosis. Integrating the compound-target network and stroke-related PPI network, we found that Akt1, HIF-1α and ITGB2 may play key roles in the treatment of stroke. The experiments demonstrated that oxycurcumenol may prevent PC12 cells from oxidative stress-induced cell damage. Our study indicates that XNJ has an effect on stroke by protecting neuro cells from oxidative stress-induced cell damage via HIF1α, and the research strategy at the systems pharmacology level is feasible to reveal the mechanisms of novel lead compounds from natural products.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmacological Sciences - Volume 136, Issue 1, January 2018, Pages 16-25
Journal: Journal of Pharmacological Sciences - Volume 136, Issue 1, January 2018, Pages 16-25
نویسندگان
Yuhua Chen, Yue Sun, Wende Li, Hong Wei, Tianlin Long, Hua Li, Quanhua Xu, Wei Liu,