دانلود مقالات ISI درباره Sh2 + ترجمه فارسی

کالمدولین به عنوان یک پروتئین لینکر و تنظیم کننده پروتئین آداپتور / داربست

Calmodulin as a protein linker and a regulator of adaptor/scaffold proteins

Keywords: AC; adenylyl cyclase; ALG-2; apoptosis-linked gene 2 product; Alix; ALG-2-interacting protein X; Bcl10; B-cell lymphoma/leukemia protein 10; CaM; calmodulin; CaM-BD; CaM-binding domain; CaM-BP; CaM-binding protein; CARD; caspase-recruitment domain; Carma1

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

گام برداشتن از سایه: پروتئین تروسین فسفاتاز پروتئین و پروتئین تومور

Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases

Keywords: ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CLL; B-cell chronic lymphocytic leukemia; CML; chronic myelogenous leukemia; ERK; extracellular signal-regulated kinase; FN3; fibronectin type-III (domain); GBM; glioblastoma multiforme; JMML

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

نقش مولکول های کوچک مهار کننده پروتئین کیت پروتئین - تیروزین کیناز در درمان اختلالات نئوپلاستی

The role of small molecule Kit protein-tyrosine kinase inhibitors in the treatment of neoplastic disorders

Keywords: AS; activation segment; CS or C-spine; catalytic spine; CL; catalytic loop; CTT; carboxyterminal tail; D1; immunoglobulin-like domain-1; EGFR; epidermal growth factor receptor; GIST; gastrointestinal stromal tumors; GK; gatekeeper; GRL; Gly-rich loop; KD;

دانلود رایگان متن کامل مقاله ISI 77 صفحه سال انتشار : 2018 سفارش ترجمه

نقش کاپرف سلول در بیماری های کبدی

The role of Kupffer cells in hepatic diseases

Keywords: APCs; antigen-presenting cells; DAMPs; danger-associated molecular patterns; DCs; Donor-derived dendritic cells; ET; endotoxin tolerance; FFA; free fatty acids; Gsdmd; gasdermin D; HDAC11; Histone deacetylase 11; HFD; high fat diet; HMGB1; high mobility g

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

انتقال و سازگاری متقابل و تعاملی که عامل عملکرد پروتئین گیرنده غشایی است

Conformational transitions and interactions underlying the function of membrane embedded receptor protein kinases

Keywords: RTK; receptor tyrosine kinase; TKL; tyrosine kinase-like receptor; GPI-AP; glycosylphosphatidylinositol-anchored protein; SH2; Scr homology 2 domain; TMD; transmembrane domain; ECD; extracellular domain or ectodomain; ICD; intracellular domain; JM; juxtam

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

سلول های بنیادی و بیماری های قلبی - ترمز یا شتاب دهنده؟

Stem cells and heart disease - Brake or accelerator?

Keywords: ACC; American College of Cardiology; acLDL; acetylated-low density lipoprotein; AHA; American Heart Association; ALL; acute lymphoblastic leukemia; ANG1; angiopoietin 1; ATMP; Advanced Therapy Medicinal Product; BM; bone marrow; BMSC; bone marrow-derived

دانلود رایگان متن کامل مقاله ISI 80 صفحه سال انتشار : 2017 سفارش ترجمه

افزایش دهنده انسولین فیگاماسیون مهاجرت سلول سرطانی سرطان کولورکتال: نقش فسفریلاسیون سرین و تعامل با سرطان پستان، مقاومت ضد استروژن 3 پروتئین

Human enhancer of filamentation 1-induced colorectal cancer cell migration: Role of serine phosphorylation and interaction with the breast cancer anti-estrogen resistance 3 protein

Keywords: BCAR3; breast cancer anti-estrogen resistance 3; Cas; Crk-associated substrate; CHAT-H; Cas/HEF1-associated signal transducer-hematopoietic; CHX; cycloheximide; CRC; colorectal cancer; FAK; focal adhesion kinase; GEF; guanine nucleotide-exchange factor; H

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

کشف سیگنالینگ فسفوریلاسیون پویا با استفاده از طیف سنجی جرمی

Uncovering dynamic phosphorylation signaling using mass spectrometry

Keywords: AEX; anion exchange chromatography; CID; collision induced dissociation; DHB; 2,5-dihydroxybenzoic acid; ECD; electron capture dissociation; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFRvIII; epidermal growth factor receptor v

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

فسفولیپید: یک روغن چرخ دار؟ از ایمنی هومورال

Phospholipids: “Greasing the wheels” of humoral immunity

Keywords: AP-1; activator protein-1; BLNK; B cell linker protein; BTK; Bruton's tyrosine kinase; CCT; choline cytidylyltransferase; CDP-choline; cytidine diphosphocholine; CEPT1; choline/ethanolamine phosphotransferase 1; Cer; ceramide; CK; choline kinase; CPT1; ch

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

گیرنده های سطحی سلول های نوتروفیل و مسیرهای انتقال سیگنال داخل سلولی آنها

Neutrophil cell surface receptors and their intracellular signal transduction pathways

Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Systems pharmacology dissection of the anti-stroke mechanism for the Chinese traditional medicine Xing-Nao-Jing

Keywords: Xing-nao-jing; Systems pharmacology; Stroke; Oxidative stress; HIF1α; XNJ; Xing-Nao-Jing; DL; Drug-likeness; BBB; Brain-blood-barrier; PPI network; Protein-protein interaction network; siRNA; Small interfering RNA; HIF; Hypoxia-inducible factor; AKT; R

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes

Keywords: Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells

Keywords: Abl; ableson kinase; ABR; actin binding repeat; Arg; ableson related gene kinase; Arp2/3; actin related protein 2/3; ATAT1; alpha-tubulin N-acetyltransferase 1; DMEM; Dulbecco's modified Eagle's medium; DOX; doxycycline; Erk; extracellular signal-re

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

SOCS-1 ameliorates smoke inhalation-induced acute lung injury through inhibition of ASK-1 activity and DISC formation

Keywords: SOCS-1; suppressor of cytokine signaling-1; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; SAECs; small airway epithelial cells; GFP; green fluorescent protein; SH2; Src homology 2; ASK-1; apoptosis signal-regulating kinase-1; DISC; de

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of new benzensulfonamide derivatives as tripedal STAT3 inhibitors

Keywords: Antitumor activity; Sulfonamide; Selectivity; Structure-based drug design; STAT3 phosphorylation; Apoptosis; DMSO; dimethyl sulfoxide; Erk; extracellular regulated kinase; rt; room temperature; MTT; 3-4, 5-dehyl-al-2-y]-2, 5-dphnetrazolium bromide; SH2;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Ca2+ signaling and Src-kinases-controlled cellular functions

Keywords: Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function

Keywords: βGal; β-Galactosidase; Aβ; amyloid-β; Abl; Abelson murine leukemia viral oncogene homolog; AD; Alzheimer's disease; AMPAR; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; BLA; basolateral amygdala; CaMKI

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

STAT3: The art of multi-tasking of metabolic and immune functions in obesity

Keywords: Signal transducer and activator of transcription 3; Obesity; Metabolism; Lipid; Immune; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; AOX; acyl-CoA oxidase; ARC; arcuate nucleus; ATGL; adipose triglyceride lipase; BAT; brown adipose ti

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Molecular cloning, transcriptional profiling, and subcellular localization of signal transducer and activator of transcription 2 (STAT2) ortholog from rock bream, Oplegnathus fasciatus

Keywords: STAT2; signal transducer and activator of transcription 2; JAK; Janus kinase; IL-10; interleukin-10; TYK2; tyrosine kinase 2; IFN; interferon; ISGF3; IFN-stimulated gene factor 3; ISG; IFN-stimulated gene; CREB; cyclic AMP-response element-binding protein

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3ζ chain

Keywords: T cell activation; TCR/CD3 crosslinking; CD3ζ chain; Crk adaptor proteins; Tyrosine phosphorylation; Signal transduction; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Crk; CT10 (chicken tumor virus number 10) regulator of kinase; CrkL

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

CD19, from bench to bedside

Keywords: BCR; B cell antigen receptor; SH2; Src-homology domain 2; MAPK; mitogen-activated protein kinase; PTKs; Src-family protein tyrosine kinases; PI3K; phosphatidylinositol-3 kinase; NF-κB; nuclear factor of κ-binding; IP3; inositol 1,4,5-trisphosphate; PIP2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

A Sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation

Keywords: Shh; Sonic hedgehog; BOC; Brother of CDO; CDO; cell adhesion molecular downregulated by ocogenes; JNK; Jun N-terminal kinase; EC; embryonal carcinoma cell; NPC; neural progenitor cell; DCC; deleted in colorectal cancer; ROBO; roundabout; GLI; glioma-assoc

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Imaging flow cytometry and GST pulldown assays provide new insights into channel catfish leukocyte immune-type receptor-mediated phagocytic pathways

Keywords: Phagocytosis; Immunoregulatory receptors; Intracellular signaling; Actin polymerization machinery; Imaging flow cytometry; Innate immunity; Channel catfish; Leukocyte immune-type receptors; IpLITR; channel catfish leukocyte immune-type receptor; CYT; cyto

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

As human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31

Keywords: aa; amino acid; Ad; adenovirus; CD; cytoplasmic domain; EC; endothelial cell; ECL; enhanced chemiluminescence; EGFR; epidermal growth factor receptor; GST; glutathione S-transferase; HPMEC; human pulmonary microvascular endothelial cell; HRP; horseradish

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Keywords: SH2; Src homology 2 domain; pY; phosphotyrosine; SFK; Src family kinase; ITC; isothermal titration calorimetry; TAP; tandem affinity purification; LC-MS/MS; liquid chromatography coupled to tandem mass spectrometry; TAP-MS; TAP-mass spectrometry; TEV; t

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

High-throughput thermofluor-based assays for inhibitor screening of STAT SH2 domains

Keywords: EMSA; electrophoretic mobility shift assays; FP; fluorescence polarization; HRP; Horseradish peroxidase; IPTG; isopropyl β-d-1-thiogalactopyranoside; IMAC; immobilized metal ion affinity chromatography; LB; Lysogeny broth; NTA; nitrilotriacetic acid; PVD

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

A conserved inhibitory role of suppressor of cytokine signaling 1 (SOCS1) in salmon antiviral immunity

Keywords: SOCS; JAK/STAT signaling; IPNV; SAV; Interferons; Atlantic salmon; bp; base pair; JAK; Janus kinase; IFN; Interferon; SH2; SRC-homology 2; ESS; extended SH2 domain; KIR; kinase inhibitory region; SOCS; suppressors of cytokine signaling; STAT; Signal Trans

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells

Keywords: AEBSF; 4-(2-aminoethyl)-benzolsulfonylfluorid; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; Epo; erythropoietin; EpoR; erythropoietin receptor; Erk; extracellular signal regulated kinase; FCS; fetal calf serum; Gab1; G

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells

Keywords: Abl; Abelson tyrosine kinase; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Cbl; Casitas B-lineage lymphoma; CD3ζY1-6F; CD3ζ mutant in which all 6 tyrosines were replaced by phenylalanine; Crk; CT10 (chicken tumor virus number 10) reg

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules

Keywords: Antitumor agents; Aminobenzo[b]thiophene 1, 1-dioxides; Drug-likeness properties; STAT3 phosphorylation, Apoptosis; DMSO; dimethyl sulfoxide; AKT; a serine/threonine protein kinase; Erk; extracellular regulated kinase; rt; room temperature; MTT; 3-4,5-deh

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of HC11 mouse breast epithelial cell differentiation by the E-cadherin/Rac axis

Keywords: cRac1; Cellular Rac1; CRIB; Cdc42/Rac-interactive binding; E-cadherin; Epithelial cadherin; ECL; enhanced chemiluminescence; EGF; Epidermal growth factor; GAP; GTPase activating protein; GDP; guanosine 5′-diphosphate; GEF; guanine nucleotide exchange fa

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1

Keywords: STAT6; Negative regulator; Interferon; TBK1; Zebrafish; CIP; calf intestinal phosphatase; CPE; cytopathic effect; EPC; epithelioma papulosum cyprini; GAS; interferon gamma activated sequence; IFN; interferon; IRF; IFN regulatory factor; IRF3; interferon r

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

The C1 domain of Vav3, a novel potential therapeutic target

Keywords: DAG; diacylglycerol; PKC; protein kinase C; GEF; guanine nucleotide exchange factor; PMA; phorbol 12-myristate 13-acetate; PDBu; phorbol 12,13-dibutyrate; CH domain; calponin homology domain; AD; acidic domain; DH; Dbl homology; PH; Pleckstrin homology; S

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular characterization and expression analysis of olive flounder (Paralichthys olivaceus) phospholipase C gamma 1 and gamma 2

Keywords: Phospholipase C gamma 1 (PLCG1); Phospholipase C gamma 2 (PLCG2); Olive flounder; Paralichthys olivaceus; cDNA cloning; mRNA expression; PLC; phosphoinositide-specific phospholipase C; PKC; protein kinase C; PLCG; phospholipase C gamma; SH2; Src homology

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

Direct coupling of the HER4 intracellular domain (4ICD) and STAT5A signaling is required to induce mammary epithelial cell differentiation

Keywords: 4ICD; HER4 intracellular domain; ATCC; American type culture collection; EGF; epidermal growth factor; EGFP; enhanced green fluorescent protein; EGFR; epidermal growth factor family; ERα; estrogen receptor alpha; FBS; fetal bovine serum; HEK; human embry

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation but not activation

Keywords: Cys; cysteine; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; GPCR; G protein-coupled receptor; HEK 293; human embryonic kidney 293; HPK1; hematopoietic progenitor kinase 1; MST; mammalian Ste20 kinase; MAP4K; MAP kinase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Immunoreceptors on neutrophils

Keywords: ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12 kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility

Keywords: CDM; cell-derived matrix; ECM; extracellular matrix; NTC; nontargeting control; PBS; phosphate-buffered saline; sh1; shRNA1; sh2; shRNA2; shRNA; short hairpin RNA; UCMD; Ullrich congenital muscular dystrophy;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID

Keywords: PLC; inositol-phospholipid-specific phospholipase C; SH2; Src homology domain 2; SH3; Src homology domain 3; PH; pleckstrin homology domain; spPH; split PH domain; PCI; phospholipase C inhibitor peptide; Rac; Ras-related C3 botulinum toxin substrate; BCR;

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2016 سفارش ترجمه

Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment

Keywords: APRIL; a proliferation-inducing ligand; ATM; ataxia telangiectasia mutated; BAFF; B-cell activating factor; BAFFR; BAFF receptor; BAG6; BCL2-associated athanogene 6; BCMA; B-cell maturation antigen; BCL2; B-cell lymphoma 2; BCR; B cell receptor; bFGF; bas

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2016 سفارش ترجمه

SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment

Keywords: 8-Chloro-cyclic AMP; SHC1; AMP-activated protein kinase; p38 MAP kinase; Cancer therapy; 8-Cl-cAMP; 8-Chloro-cyclic AMP; PKA; cyclic AMP-dependent protein kinase; AMPK; AMP-activated protein kinase; p38 MAPK; p38 mitogen-activated protein kinase; SHC1; Sr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing Zeta Associated Protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells

Keywords: Zeta Associated Protein-70 kD (ZAP-70); Syk family kinase; T-cell receptor; Signal transduction; Fluorescence resonance energy transfer (FRET); Biosensor; ZAP-70; Zeta Associated Protein 70 kD; SH2; Src homology 2; LAT; Linker for Activation of T cells; P

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and evaluation of XZH-5 analogues as STAT3 inhibitors

Keywords: STAT3; Inhibitor; SARs; SH2; Small organic molecule; Molecular docking

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

ShcC proteins: Brain aging and beyond

Keywords: ShcC adaptor proteins; Signaling; Aging; Brain ischemia; Brain tumors; Immunity; Aβ; beta-amyloid; AD; Alzheimer's disease; Akt; protein kinase B (PKB); ALK; anaplastic lymphoma kinase (receptor tyrosine kinase); APP; alpha-amyloid precursor protein; ARD

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3

Keywords: mAb; monoclonal antibody; pAb; polyclonal antibody; H4K20me3; histone H4 at lysine 20 tri-methylation; H4K16ac; histone H4 at lysine 16 acetylation; H4K20me1; histone H4 at lysine 20 mono-methylation; H4K20me2; histone H4 at lysine 20 di-methylation; ChIP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members

Keywords: 5-HT; 5-hydroxytryptamine, serotonin; A549; non-small cell lung cancer cell line; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; Aire; autoimmune regulator; AP-1; activator protein 1; APP; amyloid precursor protein; AREB6; Z

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Novel aminotetrazole derivatives as selective STAT3 non-peptide inhibitors

Keywords: STAT3; Small-molecule inhibitor; Aminotetrazole; Anticancer drug; Inflammation; STAT; signal transducer and activation of transcription; SH2; Src Homoly 2; Th; T helper; OSM; oncostatin M; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Structural perspective of ARHI mediated inhibition of STAT3 signaling: An insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinβ

Keywords: ARHI; Aplasia Ras Homologue member I; STAT3; Signal Transducer and Activator of Transcription 3; NTD; N-terminal domain; CCD; Coiled-coil domain; DBD; DNA binding domain; LD; Linker domain; SH2; Src-homology-2 domain; TAD; transactivation domain; LOH; los

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2)

Keywords: HD; Huntington's disease; Htt; huntingtin; Grb2; growth factor receptor binding protein 2; Sos1; Son of Sevenless homolog 1; Gab1; Grb2 associated binding protein 1; SH2; Src homology 2; SH3; Src homology 3; N-SH3; N-terminal SH3 domain; C-SH3; C-terminal

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Investigation of JAK1 and STAT3 polymorphisms and their gene-gene interactions in nonspecific digestive disorder of rabbits

Keywords: JAK1; Janus kinase 1; STAT3; signal transducer and activator of transcription 3; cSNPs; coding single nucleotide polymorphisms; SH2; Src homology-2 domains; NSDD; nonspecific digestive disorder; IBD; inflammatory bowel disease; CD; Crohn's disease; UC; ul

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه