دانلود مقالات ISI درباره Sh2 + ترجمه فارسی

Research ArticleNintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity

Keywords: HCC; hepatocellular carcinoma; Ab; antibody; IP; immunoprecipitation; p-STAT3; phosphorylated STAT3; PTPs; protein tyrosine phosphatases; SH2; Src homology region 2; SHP-1; SH2 domain-containing phosphatase 1; STAT3; signal transducer and activator of tra

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Transcriptome analysis of grain-filling caryopses reveals the potential formation mechanism of the rice sugary mutant

Keywords: RNA-Seq; RNA sequencing; FDR; false discovery rate; DAF; day after flowering; DEGs; differentially expressed genes; OsAGPS; Oryza sativa ADP-glucose pyrophosphorylase small subunit; OsAGPL; Oryza sativa ADP-glucose pyrophosphorylase large subunit; AGPase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

PELP1: A review of PELP1 interactions, signaling, and biology

Keywords: AIB1; amplified in breast cancer 1; AR; androgen receptor; BCAS3; breast carcinoma amplified sequence 3; CBP; CREB binding protein; ChIP; chromatin immunoprecipitation; E2; estradiol; ER; estrogen receptor; ERRα; estrogen-related receptor alpha; FHL2; fo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V

Keywords: PDGFRA; PTPN11; SHP2; STAT5; Chronic eosinophilic leukemia; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; FLT3; Fms-like tyrosine kinase 3; FPα; FIP1L1-PDGFRα; GIST; gastrointestinal stromal tumors; MAPK; mitogen-activated protein

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL

Keywords: ESDN; endothelial and smooth muscle cell-derived neuropilin-like protein; DCBLD2; discoidin CUB and LCCL domain containing 2; CUB; complement C1r/C1s Uegf Bmp1; CrkL; CrkCT10 regulator of kinase Crk-Like; SFK; Src family tyrosine kinase; Cas; Crk-associat

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Deletion of the calmodulin-binding domain of Grb7 impairs cell attachment to the extracellular matrix and migration

Keywords: AEBSF; 4-(2-aminoethyl)-benzenesulfonyl fluoride; CaM; calmodulin; CaM-BD; calmodulin-binding domain; BPS; between PH and SH2; DAPI; 4′,6-diamidino-2-phenylindole; DMEM; Dulbecco′s modified Eagle′s medium; E-64; N-[N- (L-3-trans-carboxyirane-2-carbo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography

Keywords: STAT3; signal transducer and activator of transcription 3; SH2; src homology 2 domain; STAT3βtc; the STAT3 core consisting of amino acid residues 127-722; YFP; yellow variant of eGFP, the enhanced green fluorescent protein; Signal transducer and activa

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity

Keywords: 5-FU; 5-fluorouracil; BrdU; 5-bromo-2′-deoxyuridine; FACS; fluorescence activated cell sorting; FAK; focal adhesion kinase; GMP; granulocyte-monocyte progenitor; HPC; hematopoietic progenitor cell; KLS; c-Kit+lineage−Sca-1+; LT-HSC; long-term hemato

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia

Keywords: dFCS; dialyzed fetal calf serum; GO; Gene Ontology; IPI; International Protein Index; LTQ; linear trap quadrupole; SILAC; stable isotope labeling by amino acids in cell culture; Arg6; l-arginine-13C6,14N4; Arg10; l-arginine-13C6,15N4; Lys4; l-lysine-2H4;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Two distinct mechanisms by which phospholipase C-γ1 mediates epidermal growth factor-induced keratinocyte migration and proliferation

Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Cai; intracellular calcium; NHK; normal human keratinocytes; PLC; phospholipase C; PLC-β1; phospholipase C-β1; PLC-γ1; phospholipase C-γ1; PLC-δ1; phospholipase C-δ1; PI3K; phosph

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

From modules to medicine: How modular domains and their associated networks can enable personalized medicine

Keywords: Cancer; Domain; SH2; Tyrosine kinase; Personalized medicine; Kinase inhibitor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Biophysical studies with AICD-47 reveal unique binding behavior characteristic of an unfolded domain

Keywords: APP; amyloid precursor's protein; AICD; APP-intracellular C-terminal domain; AD; Alzheimer's disease; SH2; Src homology 2; PTR and pY; phosphorylated tyrosine; IUD; intrinsically unstructured domain; Grb2; growth factor receptor binding protein 2, TFE

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Phosphosite conservation in single domain orthologs versus paralogs: A way to combine differential regulation with redundant core functions

Keywords: EST; expressed sequence tag; ADF; actin depolymerizing factor; EVH; Ena/VASP homology; PtdIns(4,5)P2; 1-(3-sn-Phosphatidyl)-d-myo-inositol 4,5-bis(phosphate); SH2; src homology 2; SH3; src homology 3; Single domain protein; Sequence conservation; Actin bi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

Keywords: AD; Alzheimer's disease; AKT; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor; aPKC; atypical protein kinase C; APP; amyloid-β precursor protein; ATG; AuTophaGy-related; BDNF; brain-derived neurotrophic factor; C/EBP; C

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The application of modular protein domains in proteomics

Keywords: pTyr; phosphotyrosine; PTM; post-translational modification; MS; mass spectrometry; PSSM; position specific scoring matrix; SH2; Src homology 2; SH3; Src homology 3; WW; tryptophan tryptophan; PDZ; post synaptic density protein 95-disks large protein 4-zo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and structural basis for a novel interaction between Vav2 and Arap3

Keywords: GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; SH2; Src homology 2; pY; phosphotyrosine; PV; pervanadate; MD; molecular dynamics; Vav2; Arap3; SH2 domain; NMR; Protein-peptide interaction; Complex structure;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Channel catfish leukocyte immune-type receptor mediated inhibition of cellular cytotoxicity is facilitated by SHP-1-dependent and -independent mechanisms

Keywords: IpLITRs; Ictalurus punctatus leukocyte immune-type receptors; SH2; Src homology 2; SHP; Src homology 2 domain-containing cytoplasmic phosphatase; Csk; C-terminal Src kinase; ITAM; immune receptor tyrosine-based activation motif; SFK; Src-family protein ty

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding

Keywords: TKB; tyrosine kinase binding; SH2; Src homology 2; SPR; surface plasmon resonance; EGFR; epidermal growth factor receptor; Met; hepatocyte growth factor receptor; Cbl; casitas B-lineage lymphoma; c-Casitas B-lineage lymphoma tyrosine kinase binding domain

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function

Keywords: PI3Kδ; phosphoinositide 3-kinase delta; PIP3; phosphoinositide 3,4,5-triphosphates; SH2; Src homology-2; PH; pleckstrin homology; KD; kinase-dead; KO; knockout; BCR; B cell receptor; GPCR; G protein-coupled receptor; TCR; T cell receptor; FcεRI; high af

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Expansion of European vacA and cagA alleles to East-Asian Helicobacter pylori strains in Cambodia

Keywords: cag PAI; cag pathogenicity island; EPIYA; Glu-Pro-Ile-Tyr-Ala; GC; Gastric carcinoma; SH2; cytoplasmic Src homology 2; SHP-2; Src homology 2 phosphatase; NFAT; nuclear factor of activated T cells; H. pylori; cagA; vacA; Recombination; Genetic population;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Several agents and pathways regulate lipolysis in adipocytes

Keywords: Lipolysis; Adipose tissue; Intracellular signalling pathways; Hormone-sensitive lipase; Adipose triglyceride lipase; Antilipolysis; ACTH; adrenocorticotrophin hormone; AdPLA; adipose-specific phospholipase A2; Ang II; angiotensin II; ANP; atrial natriuret

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The multiple roles of amphiregulin in human cancer

Keywords: AREG; amphiregulin; TACE; tumor-necrosis factor-alpha converting enzyme; ADAM; a disintegrin and metalloproteinase; CTF; carboxy-terminal fragment; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFR-TKI; epidermal growth factor rec

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

FES kinase participates in KIT-ligand induced chemotaxis

Keywords: Tyrosine kinase; c-kit; c-fes; Fps; Cell signalling; Migration; SCF; stem cell factor; FBS; foetal bovine serum; SH2; Src-homology domain-2; WT; wild-type; HBSS; Hanks' balanced salt solution;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells

Keywords: TRAP; transmembrane adapter protein; NTAL; non-T cell activation linker; LIME; lymphocyte-specific protein tyrosine kinase (Lck)-interacting membrane protein; LAT; linker for activation of T cells; PAG; protein associated with glycosphingolipid-enriched m

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

START-GAP1/DLC1 is localized in focal adhesions through interaction with the PTB domain of tensin2

Keywords: DLC; deleted in liver cancer; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; PLC; phospholipase C; FAT; focal adhesion targeting; PKC; protein kinase C; PTB; phosphotyrosine binding; PtdIns(4,5)P2; phosphatidylinositol 4,5-bispho

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Novel high-throughput screening system for identifying STAT3–SH2 antagonists

Keywords: STAT3; SH2; Transcription; Anticancer; Screening; Porphyrin

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

The XLP syndrome protein SAP interacts with SH3 proteins to regulate T cell signaling and proliferation

Keywords: SAP; SH2D1A; SH2; SH3; NCK; Fyn; X-linked lymphoproliferative syndrome; T cell

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening

Keywords: Virtual screening; Catechol; Stat3; SH2; Inhibitors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

A photoswitchable ITAM peptidomimetic: Synthesis and real time surface plasmon resonance (SPR) analysis of the effects of cis–trans isomerization on binding

Keywords: FcεRI; Syk; ITAM; SH2; Azobenzene; Conformational photoswitch; Surface plasmon resonance

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally

Keywords: Allergy and inflammation; anaphylactic shock; degranulation; druglike compound; mast cells/basophils; tyrosine kinase; Syk; BMMC; Bone marrow-derived mast cell; C-13; Compound 13; ITAM; Immunoreceptor tyrosine-based activation motif; LAT; Linker for act

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

The nerve growth factor and its receptors in airway inflammatory diseases

Keywords: ADAM; a disintegrin and metalloprotease domain; AP-1; activating protein 1; AP-2; clathrin adaptative protein-2; APPL; amyloid precursor protein-like; ARMS; ankyrin repeat-rich membrane spanning; BDNF; brain-derived neurotrophic factor; bFGF; basic fibrob

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2008 سفارش ترجمه

Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4

Keywords: Crk; Adaptor; Signaling; Brain; Glioblastoma; Cancer; SH2; Invasion; Adhesion; Motility

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

The structure–activity relationship of the series of non-peptide small antagonists for p56lck SH2 domain

Keywords: T-cell inhibition; Non-peptide; Antagonist; Inhibitor; SH2; Binding affinity

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Role of water molecules for binding inhibitors in the SH2 domain of Grb2: A molecular dynamics study

Keywords: Grb2 SH2; Molecular dynamics; Solvent effects; Water bridging; Ligand binding; Drug design; EGF-R; epidermal growth factor receptor; Grb2; growth factor receptor bound protein 2; IC50; concentration required for 50% inhibition; MAPK; mitogen-activated pro

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2007 سفارش ترجمه

A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9

Keywords: Tim-3; Tim-1; Kim-1; HAVcr; Galectin-9; SH2; ITK; T-cells; Atopy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Involvement of the SH3 domain in Ca2+-mediated regulation of Src family kinases

Keywords: c-Src; c-Yes; Tyrosine kinases; Calcium; MDCK cells; SH3 domain; EDTA; ethylene dinitrilo-tetraacetic acid; GST; glutathione-S-transferase; GT; glutathione; IVKA; in vitro kinase assays; IVRA; in vitro reconstitution assays; MDCK; Madin-Darby canine cel

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Lck couples Shc to TCR signaling

Keywords: Shc; Lck; TCR; LAT; ZAP-70; PTB; SH2; SH3

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K

Keywords: PI3K; phosphatidyl inositol 3′OH-kinase; SH2; SH3; src-homology 2; 3; S473; serine 473; TetR; bacterial tetracycline repressor-it contains a dimerization motive which has no mammalian homologue; T308; threonine 308; Y418; tyrosine 418; NPM/ALK; Intera

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Molecular cloning and expression analysis of a macrophage-colony stimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss

Keywords: M-CSF; macrophage colony-stimulating factor; CSF-1; colony-stimulating factor-1; M-CSFR; M-CSF receptor; CSF-1R; CSF-1 receptor; LPS; lipopolysaccharide; IFN; interferon; IL-1; interleukin-1; TNF; tumor necrosis factor; G-CSF; granulocyte-CSF; SH2; Src ho

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

The p95-100 kDa ligand of the T cell-specific adaptor (TSAd) protein Src-homology-2 (SH2) domain implicated in TSAd nuclear import is p97 Valosin-containing protein (VCP)

Keywords: T cell; Signal transduction; TSAd; SH2; VCP; Nuclear import;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

SOCS genes: Critical regulators of cytokine signaling and immune responses

Keywords: IL; interleukin; IFN; interferon; TNF; tumor necrosis factor; IBD; inflammatory bowel diseases; RA; rheumatoid antithesis; LPS; lipopolysaccharide; TLR; toll-like receptor; KIR; kinase inhibitory region; STAT; signal transducers and activators of the tran

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Coupling phosphoryl transfer and substrate interactions in protein kinases

Keywords: Cbp; Csk binding protein; Cbp peptide; phosphotyrosine peptide derived from Cbp with sequence ISAMpYSSVMK; Csk; COOH terminal Src kinase; Kemptide; peptide substrate with sequence LRRASLG; Npl3; nuclear protein localization 3; PKA; cAMP-dependent protein

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes

Keywords: TCR; T cell receptor; HIV-1; human immunodeficiency virus type 1; LTR; long terminal repeat; CHO; Chinese hamster ovary; PBS; phosphate-buffered saline; BSA; bovine serum albumin; PI3K; phosphatidylinositol 3′-kinase; PP1; 4-amino-5-[4-methylphenyl]-7-[

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Inactivation of tensin3 in mice results in growth retardation and postnatal lethality

Keywords: ECM; extracellular matrix; EGFR; epidermal growth factor receptor; FAB; focal adhesion binding; SH2; Src homology 2; PTB; phosphotyrosine-binding; SRS; Silver-Russell syndrome; Tensin; Focal adhesion; Growth retardation; Postnatal lethality; Alveogenesi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Comparative expression profiles of ShcB and ShcC phosphotyrosine adapter molecules in the adult brain

Keywords: Shc molecules; signal transduction; adult brain; mature neurons; neuronal survival; CH; collagene homology domain; DAB; 3,3′diaminobenzidine; Erk1/2; extracellular regulated kinases 1 and 2; PI3K-PKB; phosphatidylinosotol kinase-protein kinase B; PTB; p

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor

Keywords: Abi-1; Abl-interactor-1; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GAP; GTPase-activating protein; GEFs; guanine nucleotide exchange factors; GST; glutathione-S-transferase; mAb; monoclonal antibody; pAb; polyclonal antibody; P

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Differential signalling during B-cell maturation

Keywords: BCR; B-cell antigen receptor; DAG; diacylglycerol; GC; germinal centre; IP3; inositol-1,4,5-trisphosphate; ITAM; immunoreceptor tyrosine-based activation motif; ITIM; immunoreceptor tyrosine-based inhibition motif; MAPK; mitogen activated protein kinase;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling

Keywords: Grb10; growth factor receptor-binding protein 10; EGF; epidermal growth factor; SH2; Src homology 2; PH; pleckstrin homology; BPS; between PH and SH2; IGF-I; insulin-like growth factor-I; GIGYF; Grb10-interacting GYF protein; IRS; insulin receptor substra

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Spi-1 and Spi-B control the expression of the Grap2 gene in B cells

Keywords: BCR; B cell antigen receptor; BLNK; B cell linker protein; bp; base pair; Btk; Bruton's tyrosine kinase; cbl; Casitas b-lineage lymphoma; cDNA; complementary DNA; EDTA; ehylenediamine tetra-acetic acid; EMSA; electrophoretic mobility shift assay; FITC; fl

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه

The role of suppressors of cytokine signalling in thymopoiesis and T cell activation

Keywords: SOCS; suppressor of cytokine signalling; CIS; cytokine-induced SH2-containing protein; SH2; src-homology 2; JAK; Janus kinase; STAT; signal transducers and activators of transcription; IL; interleukin; IFN; interferon; SCF; stem cell factor; SP; single po

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2005 سفارش ترجمه