Biophysical studies with AICD-47 reveal unique binding behavior characteristic of an unfolded domain

► AICD-47 fragment possesses the attributes of a classical IUP. ► The molecule has inherent helix forming ability, substantiated by poly-flourinated alcohols. ► Molecular interaction of PAICD-47 with Grb2-SH2 domain is enthalpically favorable and entropically unfavorable process. ► Molecular surfaces of AICD-47 interactors are vastly different.