کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545804 | 1561682 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altered formation of the iron oxide nanoparticle-biocorona due to individual variability and exercise
ترجمه فارسی عنوان
تغییر شکل نانوذرات اکسید آهن-بیوکورون به علت تنوع و تمرین فردی
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کلمات کلیدی
پروتئومیکس، سم شناسی نانو، کلسترول، تری گلیسرید، ورزش، ماکروفاژ،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Nanoparticles (NPs), introduced into a biological environment, accumulate a coating of biomolecules or biocorona (BC). Although the BC has toxicological and pharmacological consequences, the effects of inter-individual variability and exercise on NP-BC formation are unknown. We hypothesized that NPs incubated in plasma form distinct BCs between individuals, and exercise causes additional intra-individual alterations. 20ânm iron oxide (Fe3O4) NPs were incubated in pre- or post-exercise plasma ex vivo, and proteomics was utilized to evaluate BC components. Analysis demonstrated distinct BC formation between individuals, while exercise was found to enhance NP-BC complexity. Abundance differences of NP-BC proteins were determined between individuals and resulting from exercise. Differential human macrophage response was identified due to NP-BC variability. These findings demonstrate that individuals form unique BCs and that exercise influences NP-biomolecule interactions. An understanding of NP-biomolecule interactions is necessary for elucidation of mechanisms responsible for variations in human responses to NP exposures and/or nano-based therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 62, September 2018, Pages 215-226
Journal: Environmental Toxicology and Pharmacology - Volume 62, September 2018, Pages 215-226
نویسندگان
Lisa M. Kobos, Sherleen Xue-Fu Adamson, Sheelagh Evans, Timothy P. Gavin, Jonathan H. Shannahan,