کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545810 | 1561683 | 2018 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CLZ-8, a potent small-molecular compound, protects radiation-induced damages both in vitro and in vivo
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
PUMA (p53 up-regulated mediator of apoptosis) is particularly important in initiating radiation-induced damage and apoptosis. It has been shown that inhibition of PUMA can provide a profound benefit for the long-term survival of the mice, without an increased risk of malignancies after irradiation. It becomes to be a potential target for developing an effective treatment aimed to protect cells from lethal radiation. CLZ-8, a novel small-molecular inhibition targeting PUMA, could have considerable protection against cell apoptosis and DNA damage. The aim of the present study is to evaluate CLZ-8â²s radioprotective ability to enhance survival rate of mice exposed to gamma radiation, prevent radiation-induced apoptosis, and repair DNA damage in cultured cells. We have determined the best effective dose in vivo is 200â¯mg/kg. This dose of CLZ-8 administered at 30â¯min before radiation can notably enhance mice survival rate. CLZ-8 ameliorates radiation-induced HUVEC cells damage and reduces apoptosis counts compared to vehicle-treated cells. Western blotting analysis indicates that CLZ-8 selectively inhibits overexpressed PUMA induced by radiation. The results demonstrate that CLZ-8 ameliorates radiation-induced cell depletion, promotes DNA recovery, and protects mice from radiation injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 61, July 2018, Pages 44-51
Journal: Environmental Toxicology and Pharmacology - Volume 61, July 2018, Pages 44-51
نویسندگان
Tian Feng, Jiyuan Liu, Nan Zhou, Libin Wang, Xueying Liu, Shengyong Zhang, Siwang Wang, Hui Chen,