PM2.5 exposure significantly improves the exacerbation of A549 tumor-bearing CB17-SCID mice

Here we investigate the effects and potential mechanisms of PM2.5 on tumor development in a lung cancer mouse model. Tumor-bearing mice (n = 32) were established and randomized into two groups: the PM2.5 or NS exposure group. Compared with the NS exposure group, mice in the PM2.5 exposure group showed an increased number of tumor nodules, increased BAL fluid protein levels, and elevated expressions of MMP1, IL1β and VEGF. Measurement of angiogenesis from blood serum using an angiogenesis antibody array revealed increased levels of 12 angiogenesis factors in mice after PM2.5 exposure. We also isolated bacteria from the upper respiratory tract of the mice and found that the microecosystem of the upper respiratory tract of tumor-bearing mice was perturbed by PM2.5 exposure. Our findings further establish a key link between PM2.5 and lung cancer and further elucidation of these mechanisms may reveal potential treatment strategies for lung cancer.