کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8546911 | 1561727 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preclinical safety evaluation of the ethanolic extract from guavira fruits (Campomanesia pubescens (D.C.) O. BERG) in experimental models of acute and short-term toxicity in rats
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کلمات کلیدی
LD50Repeated dosesUDPMCVMCHCMCHOECDALTRDWHDLAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازSafety - ایمنیMean corpuscular volume - حجم متوسط مایعCNS - دستگاه عصبی مرکزیWorld Health Organization - سازمان بهداشت جهانیOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهAcute toxicity - سمیت حادcentral nervous system - سیستم عصبی مرکزیRed cell distribution width - عرض توزیع سلول قرمزhigh density lipoprotein - لیپوپروتئین با چگالی بالاmean corpuscular hemoglobin - متوسط هموگلوبین عضلانیPreclinical studies - مطالعات پیش از موعدMean corpuscular hemoglobin concentration - میانگین غلظت هموگلوبین عروق کرونرWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Campomanesia pubescens is a fruit plant widely distributed in South America and used by the population for medicinal and nutritional purposes, with important economic and cultural value. This study evaluated the toxic potential of the ethanolic extract from C. pubescens (EEFCP) fruits through acute and short-term toxicity tests. For the acute toxicity test, female rats received a single oral dose of 2000â¯mg/kg body weight of EEFCP and were observed for 14 days. In the short-term toxicity test, male and female rats received repeated oral doses of 125, 250, 500 or 1000â¯mg/kg of EEFCP, being treated and observed for 28 days, and after the treatment period, a satellite and satellite control group remained under observation for another 14 days. No mortality, clinical and organ weight alterations were observed, indicating that LD50 is greater than 2000â¯mg/kg body weight. In addition, the doses tested did not produce significant changes in the behavioral, physiological, hematological or histopathological parameters of animals. These results demonstrate the low acute and short-term toxicity of EEFCP in rats. The data obtained are of great relevance since they provide important information about a plant species of great economic, nutritional and ethnopharmacological value.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 118, August 2018, Pages 1-12
Journal: Food and Chemical Toxicology - Volume 118, August 2018, Pages 1-12
نویسندگان
Gustavo Roberto Villas Boas, Ariany Carvalho dos Santos, Roosevelt Isaias Carvalho Souza, Flávio Henrique Souza de Araújo, Giseli Karenina Traesel, Jhony Moreira Marcelino, Ana Paula Stefanello da Silveira, Brunna Charlla Feitosa Farinelli,