کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8549256 | 1561747 | 2016 | 50 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genotoxicity assessment of the flavouring agent, perillaldehyde
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کلمات کلیدی
GLPMN-PCEJaCVAMFlavouring agentFEMAJECFAHprtOECDEFSAPCE(Q)SAR - (Q) SARDNA damage - آسیبDNAEuropean Food Safety Authority - اداره ایمنی اروپاpolychromatic erythrocytes - اریتروسیت های چند رنگیFlavor and Extract Manufacturers Association - انجمن تولید کنندگان طعم و عطرGood Laboratory Practice - تمرین خوب آزمایشگاهیQuantitative Structure Activity Relationship - رابطه فعالیت ساختاری کمیWorld Health Organization - سازمان بهداشت جهانیFood and Agriculture Organization of the United Nations - سازمان غذا و کشاورزی سازمان ملل متحدOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهGenotoxicity - سمیت ژنتیکیFAO - فائوICH - منmicronucleus or micronuclei - میکروسکوپ یا میکرونوکلئیکhypoxanthine-guanine phosphoribosyl transferase - هیپوکسانتین-گوانین فسفریبوسیل ترانسفرازnatural log - ورود طبیعیPerillaldehyde - پریلالدئیدWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Perillaldehyde, a natural monocyclic terpenoid found most abundantly in the herb perilla, has a long history of use as a flavouring ingredient to add spiciness and citrus taste to foods. Previously, it was judged to be safe by several international expert panels. To confirm the safety of flavourings placed on the European Union list of flavourings, perillaldehyde was selected by the European Food Safety Authority as a representative of a subgroup of alicyclic aldehyde flavouring substances to be evaluated for genotoxic potential. Perillaldehyde was tested in a bacterial reverse mutation assay, an in vitro micronucleus assay in human lymphocytes, an HPRT assay in mouse lymphoma cells, and a micronucleus/comet assay in Han Wistar rats. In contrast to previously published results, perillaldehyde induced mutation in Salmonella typhimurium strain TA98 in the absence of metabolic activation. The comet assay was negative for duodenum and weakly positive for liver but only at a hepatotoxic dose of perillaldehyde. All other genotoxicity assays were negative. These data do not provide an indication of any genotoxic potential for perillaldehyde, and they provide the primary basis for recent scientific opinions regarding perillaldehyde genotoxicity announced by several international organizations responsible for safety assessment of food additives and flavourings.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 97, November 2016, Pages 232-242
Journal: Food and Chemical Toxicology - Volume 97, November 2016, Pages 232-242
نویسندگان
Cheryl A. Hobbs, Sean V. Taylor, Carol Beevers, Melvyn Lloyd, Rachael Bowen, Lucinda Lillford, Robert Maronpot, Shim-mo Hayashi,