کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8549288 | 1561747 | 2016 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ptaquiloside from bracken (Pteridium spp.) inhibits tumour-infiltrating CD8+ T cells in HPV-16 transgenic mice
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کلمات کلیدی
PTQK14mAbCTLLAMP1FcγRHSQCIFN-γnuclear magnetic resonance - رزونانس مغناطیسی هستهایnatural killer - (سلول های) کشنده طبیعیbpV - bpvCD8+ T cells - CD8 + سلول های TH&E - H & EMonoclonal antibody - آنتی بادی مونوکلونالBracken - برکینNMR - تشدید مغناطیسی هستهای Cancer - سرطانHeteronuclear single quantum coherence spectroscopy - طیف سنجی تک هسته ای تک هسته ای کوانتومیFas Ligand - فاس لیگاندFasL - فاسدCytotoxic T lymphocytes - لنفوسیت های T سیتوتوکسیکmajor histocompatibility complex - مجموعه سازگاری بافتی اصلیMHC - مجموعه سازگاری بافتی اصلیwild-type - نوع وحشیHuman papillomavirus - ویروس پاپیلوم انسانیBovine papillomavirus - ویروس پاپیلوم گاویHPV - ویروس پایپلوم انسانیPtaquiloside - پتاویولوزیدlysosome-associated membrane protein 1 - پروتئین غشاء مرتبط با لیزوزوم 1Gamma-interferon - گاما اینترفرون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Bracken is a fern with worldwide distribution. Exposure to bracken toxins such as ptaquiloside is hypothesized to increase the risk of papillomavirus-related cancers of the upper digestive tract. Ptaquiloside is thought to be an immunosupressor, thus allowing for the development of viral lesions. We have used a human papillomavirus type 16-transgenic (K14-HPV16) mouse model to study the effects of ptaquiloside on tumour-infiltrating CD8+ T lymphocytes, which are critical players in anti-tumour immunity. HPV16+/â mice received ptaquiloside (0.5 mg/mouse/week) for 10 weeks. These were then euthanized at 30 weeks of age, along with age-matched untreated controls. Skin samples were enzymatically digested and CD8+ T cells analysed for CD107a and CD44 surface expression. Ptaquiloside-exposed HPV16+/â mice showed a significantly decreased percentage (PÂ <Â 0.05) of CD8+CD107a+ and CD8+CD44Â +Â T cells when compared with untreated HPV16+/â animals. Histologically, 100% of ptaquilosidetreated mice showed diffuse epidermal dysplasia, compared with 50% of the untreated mice. These findings suggest that ptaquiloside exerts an immunosuppressive role by decreasing CD8+ T cell activation and degranulation in HPV-induced lesions. Given the key role of CD8+ T lymphocytes against HPV-induced lesions, this effect is likely to contribute for viral persistence, tumour progression and increased aggressiveness in patients with HPV-related malignancies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 97, November 2016, Pages 277-285
Journal: Food and Chemical Toxicology - Volume 97, November 2016, Pages 277-285
نویسندگان
Carlos Santos, Pedro Ferreirinha, Hugo Sousa, Joana Ribeiro, Margarida M.S.M. Bastos, Tiago Neto, Paula A. Oliveira, Rui Medeiros, Manuel Vilanova, Rui M. Gil da Costa,