کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8552697 | 1562269 | 2018 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhalation of iron-abundant gas metal arc welding-mild steel fume promotes lung tumors in mice
ترجمه فارسی عنوان
استنشاق گاز فولاد قوس جوشکاری فولاد خلوص آهن، باعث افزایش تومورهای ریه در موش می شود
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Welding fumes were reclassified as a Group 1 carcinogen by the International Agency for Research on Cancer in 2017. Gas metal arc welding (GMAW) is a process widely used in industry. Fume generated from GMAW-mild steel (MS) is abundant in iron with some manganese, while GMAW-stainless steel (SS) fume also contains significant amounts of chromium and nickel, known carcinogenic metals. It has been shown that exposure to GMAW-SS fume in A/J mice promotes lung tumors. The objective was to determine if GMAW-MS fume, which lacks known carcinogenic metals, also promotes lung tumors in mice. Male A/J mice received a single intraperitoneal injection of corn oil or the initiator 3-methylcholanthrene (MCA; 10âμg/g) and, one week later, were exposed by whole-body inhalation to GMAW-MS aerosols for 4âhours/day x 4 days/week x 8 weeks at a mean concentration of 34.5âmg/m3. Lung nodules were enumerated by gross examination at 30 weeks post-initiation. GMAW-MS fume significantly increased lung tumor multiplicity in mice initiated with MCA (21.86â±â1.50) compared to MCA/air-exposed mice (8.34â±â0.59). Histopathological analysis confirmed these findings and also revealed an absence of inflammation. Bronchoalveolar lavage analysis also indicated a lack of lung inflammation and toxicity after short-term inhalation exposure to GMAW-MS fume. In conclusion, this study demonstrates that inhalation of GMAW-MS fume promotes lung tumors in vivo and aligns with epidemiologic evidence that shows MS welders, despite less exposure to carcinogenic metals, are at an increased risk for lung cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 409, 1 November 2018, Pages 24-32
Journal: Toxicology - Volume 409, 1 November 2018, Pages 24-32
نویسندگان
L.M. Falcone, A. Erdely, V. Kodali, R. Salmen, L.A. Battelli, T. Dodd, W. McKinney, S. Stone, M. Donlin, H.D. Leonard, J.L. Cumpston, J.B. Cumpston, R.N. Andrews, M.L. Kashon, J.M. Antonini, P.C. Zeidler-Erdely,