کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8553042 1562281 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitochondria targeting by environmental stressors: Implications for redox cellular signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Mitochondria targeting by environmental stressors: Implications for redox cellular signaling
چکیده انگلیسی
Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that some mitochondria chronically operate at a high ROS baseline. However, it is not completely understood how mitochondria adapt to persistently high ROS states and to environmental stressors that disturb the redox balance. Here we will review some of the current concepts regarding how mitochondria resist oxidative damage, how they are replaced when excessive oxidative damage compromises function, and the effect of environmental toxicants (i.e. heavy metals) on the regulation of mitochondrial ROS (mtROS) production and subsequent impact.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 391, 1 November 2017, Pages 84-89
نویسندگان
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