کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8624558 | 1567984 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Concentrations of oxidized linoleic acid derived lipid mediators in the amygdala and periaqueductal grey are reduced in a mouse model of chronic inflammatory pain
ترجمه فارسی عنوان
غلظت اسید لینولئیک مشتق شده از طریق لیپید مشتق شده در آمیگدال و خاکستری پرایکتون در یک مدل موش از درد مزمن التهابی کاهش می یابد
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کلمات کلیدی
CFATriHOMETrihydroxyoctadecenoic acidepoxyoctadecenoic acidPAGcomplete Freund's adjuvant - adjuvant دوست کاملHODE - HEADLC-MS/MS - LC-MS / MSArachidonic acid - اسید آراشیدونیکdocosahexaenoic acid - اسید داکوزاگزوائونیکdihydroxyoctadecenoic acid - اسید دی هیدروکسیوکتاکتنوئیکLinoleic acid - اسید لینولئیکhydroxyeicosatetraenoic acid - اسید هیدروکسی اسیستاترونیکhydroxyoctadecadienoic acid - اسید هیدروکسیکوکاتدکادویوئیکPolyunsaturated fatty acid - اسید چرب غیر اشباعPUFA - اسید چرب چند غیراشباعEpOME - اپومOxoode - اکسوودPeriaqueductal grey - خاکستری پرآبیDHA - دوکوساهگزائنوئیک اسیدDiHOME - دیهومLiquid chromatography-tandem mass spectrometry - طیف سنجی جرمی کروماتوگرافی مایع دو طرفهHETE - هفته
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
چکیده انگلیسی
Chronic pain is both a global public health concern and a serious source of personal suffering for which current treatments have limited efficacy. Recently, oxylipins derived from linoleic acid (LA), the most abundantly consumed polyunsaturated fatty acid in the modern diet, have been implicated as mediators of pain in the periphery and spinal cord. However, oxidized linoleic acid derived mediators (OXLAMs) remain understudied in the brain, particularly during pain states. In this study, we employed a mouse model of chronic inflammatory pain followed by a targeted lipidomic analysis of the animals' amygdala and periaqueductal grey (PAG) using LC-MS/MS to investigate the effect of chronic inflammatory pain on oxylipin concentrations in these two brain nuclei known to participate in pain sensation and perception. From punch biopsies of these brain nuclei, we detected twelve OXLAMs in both the PAG and amygdala and one arachidonic acid derived mediator, 15-HETE, in the amygdala only. In the amygdala, we observed an overall decrease in the concentration of the majority of OXLAMs detected, while in the PAG the concentrations of only the epoxide LA derived mediators, 9,10-EpOME and 12,13-EpOME, and one trihydroxy LA derived mediator, 9,10,11-TriHOME, were reduced. This data provides the first evidence that OXLAM concentrations in the brain are affected by chronic pain, suggesting that OXLAMs may be relevant to pain signaling and adaptation to chronic pain in pain circuits in the brain and that the current view of OXLAMs in nociception derived from studies in the periphery is incomplete.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 135, August 2018, Pages 128-136
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 135, August 2018, Pages 128-136
نویسندگان
J.R. Jensen, M.H. Pitcher, Z.X. Yuan, C.E. Ramsden, A.F. Domenichiello,