کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8626043 | 1568362 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gender-specific desensitization of group I metabotropic glutamate receptors after maternal l-glutamate intake during lactation
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
GPCRPLCmGluRA.U.G-protein coupled receptor - G-پروتئین همراه گیرندهl-Glu - l-glul-glutamate - ال گلوتاماتCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیLactation - شیردهیphospholipase C - فسفولیپاز CNeonatal brain - مغز نوزادarbitrary units - واحد دلخواهMetabotropic glutamate receptor - گیرنده گلوتامات متابوتروپیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Gender-specific desensitization of group I metabotropic glutamate receptors after maternal l-glutamate intake during lactation Gender-specific desensitization of group I metabotropic glutamate receptors after maternal l-glutamate intake during lactation](/preview/png/8626043.png)
چکیده انگلیسی
In the present work we have studied the effect of maternal intake of l-Glutamate (l-Glu) (1â¯g/L) during lactation on group I mGluR transduction pathway in brain plasma membrane from 15 days-old neonates. Results obtained have shown that maternal l-glutamate intake did not significantly affect neither weights of pups nor negative geotaxis reflex, an index of neurobehavioral development, but increased l-Glu plasma level in both male and female neonates. In male neonates, maternal l-Glu intake evoked a loss of mGluR1 whereas no variation on mGluR5 was observed as revealed by Western-blotting assay. The loss of mGlu1R was accompanied by a decrease on l-Glu-stimulated phospholipase C activity suggesting, therefore, a loss of group I mGluR functionality. Concerning female neonates, no variations were detected neither mGluR1 nor mGluR5 and group I mGluR functionality was also preserved.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 68, August 2018, Pages 10-16
Journal: International Journal of Developmental Neuroscience - Volume 68, August 2018, Pages 10-16
نویسندگان
Antonio López-Zapata, David AgustÃn León-Navarro, MarÃa Crespo, Mairena MartÃn,