کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8628690 | 1568701 | 2018 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute infection with Strongyloides venezuelensis increases intestine production IL-10, reduces Th1/Th2/Th17 induction in colon and attenuates Dextran Sulfate Sodium-induced colitis in BALB/c mice
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کلمات کلیدی
DSSIFN-γDPIi.p.IBDNKTConARTCT helperEPOMLNTNBSSPFDNBSMieloperoxidaseConcanavalin-APBSTGF-βMPO - DFOeosinophil peroxidase - ائوزینوفیل پراکسیدازTrinitrobenzene sulfonic acid - اسید سولفونیک Trinitrobenzeneperiodic acid-Schiff - اسید فسفریک SchiffColon inflammation - التهاب کولونimmunoglobulin - ایمونوگلوبولینGamma interferon - اینترفرون گاماinterleukin - اینترلوکینinflammatory bowel diseases - بیماری های روده ای التهابیTransforming Growth Factor Beta - تبدیل بتا فاکتور رشدELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاMucus production - تولید موکوسspecific pathogen-free - خاص بدون پاتوژنintraperitoneal - داخل صفاقیdinitrobenzene sulfonic acid - دینیتروبنزن سولفونیک اسیدdays post-infection - روز بعد از عفونتDextran sulfate sodium - سولفات سدیم دکسترانnatural killer T - قاتل طبیعی TPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریPAS - نهhematoxylin-eosin - هماتوکسیلین ائوزینoptical density - چگالی نوریUlcerative colitis - کولیت اولسراتیوDSS-induced colitis - کولیت ناشی از DSSmesenteric lymph nodes - گره های لنفاوی مزانتریک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Helminth infection can reduce the severity of inflammatory bowel disease. However, the modulatory mechanisms elicited by helminth infection are not yet fully understood and vary depending on the experimental model. Herein we evaluated the effect of acute infection of BALB/c mice with Strongyloides venezuelensis on the clinical course of ulcerative colitis induced by Dextran Sulfate Sodium (DSS) treatment of these animals. For the experiments, S. venezuelensis-infected BALB/c mice were treated orally with 4% DSS solution for seven days. As controls, we used untreated S. venezuelensis infected, DSS-treated uninfected, and untreated/uninfected BALB/c mice. During DSS treatment, mice from the different groups were compared with regards to the clinical signs related to the severity of colitis and intestinal inflammation. Mice acutely infected with S. venezulensis and treated with DSS had reduced clinical score, shortening of the colon, and tissue inflammation. Moreover, DSS-treated and infected mice showed reduced IL-4, INF-γ, and IL-17 levels and increase of IL-10 production in the colon and/or in the supernatant of mesenteric lymph nodes cell cultures that resulted in lower eosinophil peroxidase and myeloperoxidase activity in colon homogenates, when compared with DSS-treated uninfected mice. DSS-treated infected mice also preserved the intestine architecture and had normal differentiation of goblet cells and mucus production in the colon mucosa. In conclusion, the data indicate that the clinical improvement reported in DSS-treated infected mice was accompanied by the lower production of Th1/Th2/Th17 pro-inflammatory cytokines, stimulation of IL-10, and induction of mucosal repair mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 111, November 2018, Pages 72-83
Journal: Cytokine - Volume 111, November 2018, Pages 72-83
نویسندگان
Vanessa Fernandes Rodrigues, Márcia Paulliny Soares Bahia, Núbia Rangel Cândido, João Marcelo Peixoto Moreira, Vinicius Gustavo Oliveira, EmÃlia Souza Araújo, Jailza Lima Rodrigues Oliveira, Michelle de Carvalho Rezende, Ary Jr.,