کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8628702 1568702 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pro- and anti-inflammatory biomarkers and traumatic brain injury outcomes: A review
ترجمه فارسی عنوان
بیومارکرهای پروتئینی و ضد التهابی و نتایج آسیب مغزی: بررسی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Traumatic Brain Injury (TBI) triggers a cascade of secondary biological and physiological effects that are variable, depending on the severity, location, and complexity of the injury. Improved diagnosis and prognosis of brain injury may be possible by examining changes in protein biomarker concentrations and, determining their role in long-term outcomes may improve treatment. One promising direction for biomarker research surrounds pro- and anti-inflammatory cytokines which may have utility for predicting short and long-term prognosis after TBI, and may also be therapeutic targets in shaping neuronal recovery following a TBI. The purpose of this review is to examine the relationship between TBI symptoms and changes in pro- and anti- inflammatory biomarkers. Eighteen (18) published articles met criteria for inclusion. Fourteen studies focused on individuals with severe TBI. Increased levels of interleukin (IL)-6, IL-1, IL-8, IL-10 and tumor necrosis factor alpha (TNFα) were associated with worse outcomes, with most studies focusing on morbidity and mortality. It is important to identify the biochemical changes that may influence or initiate the presentation of health outcomes after a TBI. Earlier identification of symptoms associated with these biochemical changes can be used to support better treatment planning, targeted interventions and ultimately, improvement in patient outcomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 110, October 2018, Pages 248-256
نویسندگان
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