کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8633038 | 1569028 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metabolic strategies for the degradation of the neuromodulator agmatine in mammals
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Metabolic strategies for the degradation of the neuromodulator agmatine in mammals Metabolic strategies for the degradation of the neuromodulator agmatine in mammals](/preview/png/8633038.png)
چکیده انگلیسی
Agmatine results from the decarboxylation of L-arginine in a reaction catalyzed by arginine decarboxylase (ADC), and can be converted to either guanidine butyraldehyde by diamine oxidase (DAO) or putrescine and urea by the enzyme agmatinase (AGM) or the more recently identified AGM-like protein (ALP). In rat brain, agmatine, AGM and ALP are predominantly localised in areas associated with roles in appetitive and craving (drug-reinstatement) behaviors. Thus, inhibitors of AGM or ALP are promising agents for the treatment of addictions. In this review, the properties of DAO, AGM and ALP are discussed with a view to their role in the agmatine metabolism in mammals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 81, April 2018, Pages 35-44
Journal: Metabolism - Volume 81, April 2018, Pages 35-44
نویسندگان
José BenÃtez, David GarcÃa, Nicol Romero, Arlette González, José MartÃnez-Oyanedel, Maximiliano Figueroa, Mónica Salas, Vasthi López, MarÃa GarcÃa-Robles, Peter R. Dodd, Gerhard Schenk, Nelson Carvajal, Elena Uribe,