کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8644545 | 1569762 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human Leukocyte Antigen class II polymorphisms among Croatian patients with type 1 diabetes and autoimmune polyglandular syndrome type 3 variant
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
T1DPTPN22CTLA4protein tyrosine phosphatase non-receptor type 22AITDTABHuman leukocyte antigens (HLA)TPOPCR-SSOGADICAFOXP3IA-2glutamic acid decarboxylase - glutamic acid dearboxylaseThyroid antibodies - آنتی بادی تیروئیدIslet cell antibodies - آنتی بادی سلولی جزیرهcytotoxic T lymphocyte antigen 4 - آنتی ژن لنفوسیت T سیتوتوکسیک 4Human leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیenzyme immunoassay - ایمونواسی آنزیم autoimmune thyroid disease - بیماری تیروئید autoimmuneGraves' disease - بیماری گریوسELISA - تست الیزاThyroid peroxidase - تیروئید پراکسیدازAutoimmune thyroiditis - تیروئیدیت اتوایمیونThyroglobulin - تیروگلوبولینType 1 diabetes (T1D) - دیابت نوع 1 (T1D)Type 1 diabetes - دیابت نوع۱odds ratio - نسبت شانس ها
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study included 161 patients: 92 patients had type 1 diabetes (T1D) while 69 patients had a combination of T1D and autoimmune thyroiditis, the so-called autoimmune polyglandular syndrome type 3 variant (APS3v). Those patients, as well as 93 controls, were typed for HLA-DRB1 and -DQB1 genes to assess their possible contribution to the development/protection of T1D with/without autoimmune thyroiditis. Both HLA-DRB1*04 and -DRB1*03 frequencies were significantly higher among T1D and APS3v patients than in controls. The frequencies of HLA-DRB1*11 and -DRB1*15 were lower among T1D patients, while HLA-DRB1*07 and -DRB1*11 occurred significantly less frequently among APS3v patients in comparison to controls. HLA-DQB1*03:01 and -DQB1*03:02 were associated with a higher risk of developing T1D and APS3v; HLA-DQB1*02 was significantly more present among APS3v patients while HLA-DQB1*03:03 was observed with a significantly lower frequency only among T1D patients. HLA-DRB1*03~DQB1*02 and HLA-DRB1*04~DQB1*03:02 were associated with both diseases. The higher frequency of HLA-DRB1*03/DRB1*03 among APS3v patients was the only significant difference in genotype frequency when compared to T1D patients, while high risk (HLA-DRB1*03/DRB1*04) and medium risk genotypes for T1D (HLA-DRB1*04/DRB1*04) occurred with similar frequencies in both patient groups. Although some of the results point toward shared genetic susceptibility of T1D and APS3v, observed differences in both susceptible/protective HLA profiles indicate the necessity of further studies in order to elucidate the pathogenesis of these diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 674, 20 October 2018, Pages 93-97
Journal: Gene - Volume 674, 20 October 2018, Pages 93-97
نویسندگان
Zorana Grubic, Natasa Rojnic Putarek, Marija Maskalan, Renata Zunec, Katarina Stingl Jankovic, Marija Burek Kamenaric, Jadranka Knezevic-Cuca, Anita Spehar Uroic, Miroslav Dumic,