کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8644720 | 1569766 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic variants of fatty acid elongase 6 in Chinese Holstein cow
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
SCCUFAsFADS1ELOVL6FADS2MUFAssFasPUFAsHWESNVsSCsPICFFA3′untranslated region - 3'untranslated منطقه3′UTR - 3'UTRSp1 - SP1Fatty acid desaturase 1 - اسید لاکتیک دیاتاز 1Polyunsaturated fatty acids - اسید چرب اشباع نشدهfatty acid desaturase 2 - اسید چرب دارونما 2fatty acid synthase - اسید چرب سنتازFree fatty acids - اسیدهای چرب آِزادsaturated fatty acids - اسیدهای چرب اشباع شدهFatty acid elongase - اسیدهای چرب اشباع شدهUnsaturated fatty acids - اسیدهای چرب غیر اشباعmonounsaturated fatty acids - اسیدهای چرب غیر اشباعmarker-assisted selection - انتخاب کمک کننده نشانگرsingle nucleotide variants - انواع تک نوکلئوتیدیMAS - بیشترHardy–Weinberg equilibrium - تعادل هاردی-وینبرگSomatic cell count - تعداد سلول های سوماتیکFatty acid synthesis - سنتز اسید چربMilk production traits - صفات تولید شیرLinkage disequilibrium - عدم تعادل پیوستگیTranscription factor Sp1 - فاکتور رونویسی Sp1Fasn - فسادpolymorphism information content - محتوای اطلاعات پلی مورفیسمSrebf - نقره ایsomatic cell score - نمره سلولی سوماتیکHeterozygosity - هتروزیگوزیتهHomozygosity - هموسیگوییChinese Holstein - هولشتاین چینیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Genetic variants of fatty acid elongase 6 in Chinese Holstein cow Genetic variants of fatty acid elongase 6 in Chinese Holstein cow](/preview/png/8644720.png)
چکیده انگلیسی
In the dairy industry, genetic variants have contributed to the improvement of milk production traits. Fatty acid elongase 6 (ELOVL6), which elongates saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs), plays a distinct role in the balance of long-chain fatty acids composition in animals. ELOVL6 catalyzes the elongation of palmitic acids (C16:0) which is the most common saturated fatty acid found in animals and also an essential precursor to synthesize other long-chain fatty acids. However, the genetic variant research of bovine ELOVL6 on milk quality traits is still unknown. Therefore, our study aimed to detect the single nucleotide polymorphism (SNPs) of bovine ELOVL6 and explored the relationship between SNPs and milk quality traits including milk yield, fat content, protein content and somatic cell score. In this study, three SNPs, including SNP1 (g16379651A>G), SNP2 (g16458976A>G) and SNP3 (g16511290A>G), have been identified in intron 3 and 3â²UTR regions of ELOVL6 in Chinese Holstein (CH) cows. Besides, the results of genetic diversity analysis, linkage disequilibrium and haplotype analysis indicated that these SNPs presented moderate polymorphisms which reflected relatively high genetic diversity. No strong linkage among these SNPs were detected in sampled population of cows. Moreover, the results of correlation analyses demonstrated that these SNPs of bovine ELOVL6 were significantly related to milk yield (Pâ¯<â¯0.05). The SNP1 was also correlated with somatic cell score, whereas the SNP3 was associated with fat content. The 21 combined genotypes (diplotypes) were highly significantly correlated (Pâ¯<â¯0.01) with milk yield. These results revealed that the genetic variants of bovine ELOVL6 influenced the milk production of CH cows. Hence, the three SNPs could be regarded as molecular markers in marker-assisted selection (MAS) of the dairy cow breeding.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 670, 5 September 2018, Pages 123-129
Journal: Gene - Volume 670, 5 September 2018, Pages 123-129
نویسندگان
Si Chen, Menglin Chai, Chen Tian, Yuzhuang Li, Tian Deng, Hui Wu, Xiaolin Liu,