کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645886 | 1569794 | 2018 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of circular RNAs in human aortic valves
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کلمات کلیدی
ANK3KEGG Orthology Based Annotation SystemcircRNAFN1miRNA response elementsMREsTIMP1TGFBR2Tbx20Smad1SMCsCASP3ECMBAVFBNRBPMmpsSCN5AErbB4RUNX2TAVCircular RNA - RNA دایره ایcircular RNAs - RNA های دایره ایArgonaute - آرگونوتHuman - انسانTissue specific - بافت خاصAortic valve - دریچه آئورتtricuspid aortic valve - دریچه آئورت tricuspidBicuspid aortic valve - دریچه آئورت دولتیSmooth muscle cells - سلول های عضله صافrunt related transcription factor 2 - عامل رونویسی مربوط به ریت 2fibronectin 1 - فیبرنکتین 1Fibrillin 1 - فیبریلین 1Extracellular matrix - ماتریکس خارج سلولیMatrix metalloproteinases - متالوپروتئیناز ماتریکسMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNAGene ontology - هستیشناسی ژنیRNA binding protein - پروتئین متصل به RNAAGO - پیشCaspase-3 - کاسپاز ۳ KOBAS - کوبا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
With the wide application of RNA-Seq technology, thousands of circular RNAs (circRNAs) have been identified in different type of tissues and cells in many organisms, but little is known on the human aortic valve expressed circRNAs. In this study, we identified all circRNAs in two calcified human aortic valves, and characterized the features of all circRNAs. A total of 5476 circRNAs were identified in human aortic valves, including 1412 (25.79%) aortic valve specific circRNAs. Next, we showed that most aortic valve specific circRNAs were derived from the exonic regions of their host genes, and majority of the host genes contained less than three circRNAs. To predict the potential function of aortic valve specific circRNAs, we performed the GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis for the host genes, and identified both microRNA (miRNA) and RNA binding protein (RBP) binding sites inside aortic valve specific circRNAs. Results showed that these host genes were involved in some aortic valve related function pathways, such as ECM-receptor interaction pathway, ErbB signaling pathway, and vascular smooth muscle contraction pathway. We also found that most aortic valve specific circRNAs harbored abundant miRNA response elements (MREs), and some aortic valve specific circRNAs could bind to RBP of interest. Functional analysis suggested that these aortic valve specific circRNAs could act as post-transcriptional regulators.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 642, 5 February 2018, Pages 135-144
Journal: Gene - Volume 642, 5 February 2018, Pages 135-144
نویسندگان
Jianle Chen, Jun Wang, Yun Jiang, Weidong Gu, Buqing Ni, Haoliang Sun, Wanjun Gu, Liang Chen, Yongfeng Shao,