کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8650341 | 1571124 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dopamine D2 receptor polymorphism (C957T) is associated with sugar consumption and triglyceride levels in West Mexicans
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dopamine D2 receptor polymorphism (C957T) is associated with sugar consumption and triglyceride levels in West Mexicans Dopamine D2 receptor polymorphism (C957T) is associated with sugar consumption and triglyceride levels in West Mexicans](/preview/png/8650341.png)
چکیده انگلیسی
Genetic variations in the dopamine receptor D2 (DRD2) may alter dopamine signaling and modify the rewarding effects of food. This study aimed to analyze the association of the C957T DRD2 polymorphism with sugar consumption in West Mexican subjects. In a cross-sectional and analytical study, a total of 215 Mexican subjects were enrolled. DRD2 genotyping was performed by an allelic discrimination assay. Habitual dietary intake and the biochemical profile were evaluated. Genotype frequencies of the C957T DRD2 polymorphism were CC (12.1%), CT (40.9%) and TT (47.0%). Carriers of the CC genotype had a higher intake of sugar (g/day) than heterozygotes (67.4â¯g vs. 41.3â¯g, pâ¯=â¯0.001) and TT homozygotes (67.4â¯g vs. 45.2â¯g, pâ¯=â¯0.004). Also, the habitual consumption of soda (daily or at least 3 times per week) was more frequent among CC genotype carriers compared with heterozygotes (81% vs. 51%, pâ¯=â¯7.5â¯Ãâ¯10â6) and TT homozygotes (81% vs. 57%, pâ¯=â¯2.4â¯Ãâ¯10â4). Furthermore, the CC genotype was associated with elevated serum triglyceride levels (>150â¯mg/dL) than the CT genotype (ORâ¯=â¯2.80, 95% CI 1.08-7.24, pâ¯=â¯0.034). In conclusion, our results suggest a genetic background associated with sugar consumption among West Mexicans, which may contribute to increases in serum triglyceride levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 194, 1 October 2018, Pages 532-537
Journal: Physiology & Behavior - Volume 194, 1 October 2018, Pages 532-537
نویسندگان
Omar Ramos-Lopez, Arturo Panduro, Ingrid Rivera-Iñiguez, Sonia Roman,