کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8651925 1573341 2018 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human Streptococcal Necrotizing Fasciitis Histopathology Mirrored in a Murine Model
ترجمه فارسی عنوان
هیستوپاتولوژی انسانی نروتوزی انسانی در مدل موش آشکار شده است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Streptococcal necrotizing fasciitis (NF) causes high morbidity and mortality despite state-of-the-art therapy. Low incidence and rapid disease progression, necessitating immediate initiation of therapy, have proven challenging aspects for setting up prospective randomized trials. This has resulted in little therapeutic progress over the past decade. The validation of reliable murine NF models to study both pathogenesis and optimized therapeutic regimens of streptococcal NF are thus essential. In this study, we characterized a murine NF model and compared the pathology with an in-depth tissue analysis of streptococcal NF in patients. We found that the streptococcal murine NF model closely reflected all histologic characteristics encountered in human streptococcal NF. This murine NF model helps understanding of human NF pathology better in a time-dependent manner and will allow studying novel therapeutic options in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of Pathology - Volume 188, Issue 7, July 2018, Pages 1517-1523
نویسندگان
, , , , , , , ,